A method based on isotonic regression estimation for identifying the maximum tolerated dose

zbMATH Open1174.62575MaRDI QIDQ5320124FDOQ5320124

Authors: Zhongzhan Zhang, Jian Tao, Xueli Wang, Ning-Zhong Shi 

Publication date: 22 July 2009

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zbMATH Keywords

phase I clinical trialstoxicity-study

Mathematics Subject Classification ID

Applications of statistics to biology and medical sciences; meta analysis (62P10) Medical applications (general) (92C50) Sequential statistical design (62L05)

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• Highest dose level for non-increased-toxicity response in longitudinal data
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• The role of minimal sets in dose finding studies

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