Incorporating overrunning data into the analysis of both primary and secondary endpoints in a sequential trial

MaRDI QIDQ3511591zbMATH OpenFDO

Authors Aiyi Liu, Chengqing Wu, Kai F. Yu

Publication date 11 July 2008

zbMATH Keywords

additional dataarm-specific analysisclinical trialsinterim analysispatient allocationsecondary endpointsstopping boundaries

Mathematics Subject Classification ID

Sequential statistical design (62L05) Sequential statistical analysis (62L10) Applications of statistics to biology and medical sciences; meta analysis (62P10)

Recommendations

• Incorporating data received after a sequential trial has stopped into the final analysis: implementation and comparison of methods
• Sequential tests and estimators after overrunning based on maximum-likelihood ordering
• Tests and confidence intervals for secondary endpoints in sequential clinical trials
• Supplementary Analysis at the Conclusion of a Sequential Clinical Trial
• Testing Secondary Hypotheses Following Sequential Clinical Trials

Cited in

(4)

• Incorporating data received after a sequential trial has stopped into the final analysis: implementation and comparison of methods
• Tests and confidence intervals for secondary endpoints in sequential clinical trials
• Sequential tests and estimators after overrunning based on maximum-likelihood ordering
• Monitoring Continuous Long-Term Outcomes in Adaptive Designs

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