Testing Secondary Hypotheses Following Sequential Clinical Trials

DOI10.1111/J.0006-341X.2000.00640.XMaRDI QIDQ4667496zbMATH OpenWikidataFDO

Authors Aiyi Liu, Ming Tan, James M. Boyett, Xiaoping Xiong

Publication date 20 April 2005

Published in Biometrics (Search for Journal in Brave)

Full work available at URL https://doi.org/10.1111/J.0006-341X.2000.00640.X

zbMATH Keywords

sequential monitoringBrownian motion approximationWhitehead's model

Mathematics Subject Classification ID

Applications of statistics to biology and medical sciences; meta analysis (62P10) Sequential statistical design (62L05) Testing in survival analysis and censored data (62N03)

Recommendations

• Supplementary Analysis at the Conclusion of a Sequential Clinical Trial
• Tests and confidence intervals for secondary endpoints in sequential clinical trials
• Improved two-stage group sequential procedures for testing a secondary endpoint after the primary endpoint achieves significance
• Inference about a secondary process following a sequential trial
• Confidence Intervals for Secondary Parameters Following a Sequential Test

Cites work

• scientific article; zbMATH DE number 3903818 (Why is no real title available?)
• A Computationally Simpler Algorithm for the UMVUE of a Normal Mean Following a Group Sequential Trial
• Clinical Trial Designs Based on Sequential Conditional Probability Ratio Tests and Reverse Stochastic Curtailing
• Information and information fractions for design and sequential monitoring of clinical trials
• Minimum variance unbiased estimation of the drift of brownian motion with linear stopping boundaries
• On the bias of maximum likelihood estimation following a sequential test
• Statistical approaches to interim monitoring of medical trials: A review and commentary
• Supplementary Analysis at the Conclusion of a Sequential Clinical Trial
• The distribution of brownian motion on linear stopping boundaries
• Unbiased estimation following a group sequential test

Cited in

(5)

• Incorporating overrunning data into the analysis of both primary and secondary endpoints in a sequential trial
• Tests and confidence intervals for secondary endpoints in sequential clinical trials
• Supplementary Analysis at the Conclusion of a Sequential Clinical Trial
• Testing a Primary and a Secondary Endpoint in a Group Sequential Design
• Improved two-stage group sequential procedures for testing a secondary endpoint after the primary endpoint achieves significance

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