Impact of population substructure on trend tests for genetic case-control association studies

DOI10.1111/J.1541-0420.2009.01264.XMaRDI QIDQ3561822zbMATH OpenOpenAlexWikidataFDO

Authors Gang Zheng, Zhaohai Li, Mitchell H. Gail, Joseph L. Gastwirth

Publication date 26 May 2010

Published in Biometrics (Search for Journal in Brave)

Full work available at URL https://doi.org/10.1111/j.1541-0420.2009.01264.x

zbMATH Keywords

allele frequency matchingbiascryptic relatednessdisease rate heterogeneitypopulation stratificationvariance distortion

Mathematics Subject Classification ID

Applications of statistics to biology and medical sciences; meta analysis (62P10) Genetics and epigenetics (92D10)

Recommendations

• Case-control association tests correcting for population stratification.
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Cites work

• From Genotypes to Genes: Doubling the Sample Size
• Genomic Control for Association Studies
• Genomic Control for Association Studies under Various Genetic Models
• scientific article; zbMATH DE number 3342611 (Why is no real title available?)
• scientific article; zbMATH DE number 3390587 (Why is no real title available?)

Cited in

(6)

• Trend tests for genetic association using population-based cross-sectional complex survey data
• The impact of population stratification on commonly used statistical procedures in population-based QTL association studies
• Assessment of Population Structure and Its Effects on Genome-Wide Association Studies
• Bayes factors in the presence of population stratification
• Population structure and cryptic relatedness in genetic association studies
• Excess false positive rate caused by population stratification and disease rate heterogeneity in case-control association studies

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