Assessment of Population Structure and Its Effects on Genome-Wide Association Studies

DOI10.1080/03610920902947188MaRDI QIDQ3645010zbMATH OpenOpenAlexWikidataFDO

Authors Hongyan Xu, Varghese George

Publication date 16 November 2009

Published in Communications in Statistics: Theory and Methods (Search for Journal in Brave)

Full work available at URL http://europepmc.org/articles/pmc2748884

zbMATH Keywords

simulationsSNPgenetic variationpopulation structuregenome-wide associationcomplex diseasesfalse positivesheterozygosity

Mathematics Subject Classification ID

Applications of statistics to biology and medical sciences; meta analysis (62P10) Genetics and epigenetics (92D10)

Recommendations

• Population structure and cryptic relatedness in genetic association studies
• Correcting for population stratification in genomewide association studies
• Multilocus estimation of genetic structure within populations
• Analysis of genetic association studies
• Controlling population structure in human genetic association studies with samples of unrelated individuals
• The impact of population stratification on commonly used statistical procedures in population-based QTL association studies
• Impact of population substructure on trend tests for genetic case-control association studies
• Population Structure and Covariate Analysis Based on Pairwise Microsatellite Allele Matching Frequencies
• Biostatistical aspects of genome-wide association studies

Cites work

• Assessing Population Differentiation and Isolation from Single-Nucleotide Polymorphism Data
• From Genotypes to Genes: Doubling the Sample Size
• Genomic Control for Association Studies
• Random partitions in population genetics
• The coalescent

Cited in

(5)

• Correspondence analysis approach for finding allele associations in population genetic study
• Controlling population structure in human genetic association studies with samples of unrelated individuals
• The impact of population stratification on commonly used statistical procedures in population-based QTL association studies
• An Eigenvalue Ratio Approach to Inferring Population Structure from Whole Genome Sequencing Data
• Assessing Population Differentiation and Isolation from Single-Nucleotide Polymorphism Data

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