Turing patterns from dynamics of early HIV infection
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PDEs in connection with biology, chemistry and other natural sciences (35Q92) Computational methods for problems pertaining to biology (92-08) Developmental biology, pattern formation (92C15) Cell movement (chemotaxis, etc.) (92C17) Medical applications (general) (92C50) Medical epidemiology (92C60)
Abstract: We have developed a mathematical model for in-host virus dynamics that includes spatial chemotaxis and diffusion across a two dimensional surface representing the vaginal or rectal epithelium at primary HIV infection. A linear stability analysis of the steady state solutions identified conditions for Turing instability pattern formation. We have solved the model equations numerically using parameter values obtained from previous experimental results for HIV infections. Simulations of the model for this surface show hot spots of infection. Understanding this localization is an important step in the ability to correctly model early HIV infection. These spatial variations also have implications for the development and effectiveness of microbicides against HIV.
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