Turing patterns from dynamics of early HIV infection
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Publication:376465
DOI10.1007/S11538-013-9834-5zbMATH Open1273.92035arXiv1209.2772OpenAlexW2337525307WikidataQ51237698 ScholiaQ51237698MaRDI QIDQ376465FDOQ376465
Authors: John M. Murray, B. I. Henry, Ognjen Stancevic, C. N. Angstmann 
Publication date: 5 November 2013
Published in: Bulletin of Mathematical Biology (Search for Journal in Brave)
Abstract: We have developed a mathematical model for in-host virus dynamics that includes spatial chemotaxis and diffusion across a two dimensional surface representing the vaginal or rectal epithelium at primary HIV infection. A linear stability analysis of the steady state solutions identified conditions for Turing instability pattern formation. We have solved the model equations numerically using parameter values obtained from previous experimental results for HIV infections. Simulations of the model for this surface show hot spots of infection. Understanding this localization is an important step in the ability to correctly model early HIV infection. These spatial variations also have implications for the development and effectiveness of microbicides against HIV.
Full work available at URL: https://arxiv.org/abs/1209.2772
Recommendations
Medical applications (general) (92C50) Medical epidemiology (92C60) PDEs in connection with biology, chemistry and other natural sciences (35Q92) Computational methods for problems pertaining to biology (92-08) Developmental biology, pattern formation (92C15) Cell movement (chemotaxis, etc.) (92C17)
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