Analysis of multiple sclerosis lesions via spatially varying coefficients

DOI10.1214/14-AOAS718zbMATH Open1454.62334arXiv1407.8406OpenAlexW3106059482WikidataQ34571240 ScholiaQ34571240MaRDI QIDQ400663FDOQ400663

Authors: Tian Ge, Nicole Müller-Lenke, Kerstin Bendfeldt, Thomas E. Nichols, Timothy D. Johnson 

Publication date: 22 August 2014

Published in: The Annals of Applied Statistics (Search for Journal in Brave)

Abstract: Magnetic resonance imaging (MRI) plays a vital role in the scientific investigation and clinical management of multiple sclerosis. Analyses of binary multiple sclerosis lesion maps are typically "mass univariate" and conducted with standard linear models that are ill suited to the binary nature of the data and ignore the spatial dependence between nearby voxels (volume elements). Smoothing the lesion maps does not entirely eliminate the non-Gaussian nature of the data and requires an arbitrary choice of the smoothing parameter. Here we present a Bayesian spatial model to accurately model binary lesion maps and to determine if there is spatial dependence between lesion location and subject specific covariates such as MS subtype, age, gender, disease duration and disease severity measures. We apply our model to binary lesion maps derived from $T_2$-weighted MRI images from 250 multiple sclerosis patients classified into five clinical subtypes, and demonstrate unique modeling and predictive capabilities over existing methods.

Full work available at URL: https://arxiv.org/abs/1407.8406

Recommendations

• Bayesian spatiotemporal modeling using hierarchical spatial priors, with applications to functional magnetic resonance imaging (with discussion)
• scientific article; zbMATH DE number 2018143
• Spatio-temporal segmentation of active multiple sclerosis lesions in serial MRI data
• A Bayesian spatial mixture model for FMRI analysis
• A lag functional linear model for prediction of magnetization transfer ratio in multiple sclerosis lesions

zbMATH Keywords

image analysisMarkov random fieldsmagnetic resonance imagingmultiple sclerosisconditional autoregresive modellesion probability mapspatially varying coefficients

Mathematics Subject Classification ID

Applications of statistics to biology and medical sciences; meta analysis (62P10) Biomedical imaging and signal processing (92C55)

Cites Work

• Functional data analysis
• Inference from iterative simulation using multiple sequences
• Multi-dimensional multivariate Gaussian Markov random fields with application to image processing
• Gaussian Predictive Process Models for Large Spatial Data Sets
• Title not available (Why is that?)
• Bias reduction of maximum likelihood estimates
• Bayesian Analysis of Binary and Polychotomous Response Data
• Covariance tapering for likelihood-based estimation in large spatial data sets
• Sampling-Based Approaches to Calculating Marginal Densities
• Stochastic Relaxation, Gibbs Distributions, and the Bayesian Restoration of Images
• Monte Carlo sampling methods using Markov chains and their applications
• Title not available (Why is that?)
• Spatial Modeling With Spatially Varying Coefficient Processes
• Generalized multilevel functional regression
• Functional generalized linear models with images as predictors
• Analysis of multiple sclerosis lesions via spatially varying coefficients
• On the distinction between the conditional probability and the joint probability approaches in the specification of nearest-neighbour systems

Cited In (11)

• Analysis of multiple sclerosis lesions via spatially varying coefficients
• Location-adjusted Wald statistics for scalar parameters
• Bayesian Lesion Estimation with a Structured Spike-and-Slab Prior
• Spatio-temporal segmentation of active multiple sclerosis lesions in serial MRI data
• Title not available (Why is that?)
• Spatial Bayesian variable selection and grouping for high-dimensional scalar-on-image regression
• GPU accelerated estimation of a shared random effect joint model for dynamic prediction
• 1D Wavelet and Partial Correlation Application for MS Subgroup Diagnostic Classification
• A spatially varying hierarchical random effects model for longitudinal macular structural data in glaucoma patients
• A comparative study of correlation coefficients in spatially MRSI-observed neurochemicals from multiple sclerosis patients
• A lag functional linear model for prediction of magnetization transfer ratio in multiple sclerosis lesions

Uses Software

• fda (R)

This page was built for publication: Analysis of multiple sclerosis lesions via spatially varying coefficients

Report a bug (only for logged in users!)Click here to report a bug for this page (MaRDI item Q400663)