Mathematical modelling and computational study of two-dimensional and three-dimensional dynamics of receptor-ligand interactions in signalling response mechanisms

DOI10.1007/S00285-013-0712-4zbMATH Open1302.92041OpenAlexW1974215082WikidataQ45191889 ScholiaQ45191889MaRDI QIDQ404786FDOQ404786

Authors: Pilar García-Peñarrubia, Juan J. Gálvez, Jesús Gálvez 

Publication date: 4 September 2014

Published in: Journal of Mathematical Biology (Search for Journal in Brave)

Full work available at URL: https://doi.org/10.1007/s00285-013-0712-4

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zbMATH Keywords

reduction of dimensionality2D and 3D receptor-ligand bindingsignalling response mechanisms

Mathematics Subject Classification ID

Systems biology, networks (92C42) Software, source code, etc. for problems pertaining to biology (92-04) Computational methods for problems pertaining to biology (92-08)

Cites Work

• Dynamics and stability of a three-dimensional model of cell signal transduction
• Spatio-temporal modelling of the NF-\(\kappa\)B intracellular signalling pathway: the roles of diffusion, active transport, and cell geometry
• Model of cell signal transduction in a three-dimensional domain

Cited In (11)

• Analysis of bulk-surface reaction-sorption-diffusion systems with Langmuir-type adsorption
• An adaptive coarse graining method for signal transduction in three dimensions
• Multiscale Analysis and Simulation of a Signaling Process With Surface Diffusion
• Modeling and genetic algorithm optimization of early events in signal transduction via dynamics of G-protein-coupled receptors: Internalization consideration
• Cross-membrane signal transduction of receptor tyrosine kinases (RTKs): from systems biology to systems pharmacology
• Markov random field modeling of the spatial distribution of proteins on cell membranes
• Coupled Bulk-Surface Free Boundary Problems Arising from a Mathematical Model of Receptor-Ligand Dynamics
• Global well-posedness for volume–surface reaction–diffusion systems
• A Coupled Ligand-Receptor Bulk-Surface System on a Moving Domain: Well Posedness, Regularity, and Convergence to Equilibrium
• Mathematical modelling of signalling in a two-ligand G-protein coupled receptor system: agonist-antagonist competition
• T cell activation: Kinetic proofreading, serial engagement and cell adhesion

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