Asymptotic limit in a cell differentiation model with consideration of transcription

Qualitative investigation and simulation of ordinary differential equation models (34C60) Asymptotic properties of solutions to ordinary differential equations (34D05) Cell biology (92C37)

Review text

Consider the cell differentiation model NEWLINE\[NEWLINE \begin{aligned} {{dy_i}\over {dt}}&=-\mu_i y_i+\Bigl(\alpha_i {{x_i^n}\over {k_i^n+x_i^n}}+\sigma_i{{S_i}\over {\rho_i+S_i}}\Bigr){1\over {1+{{x_\nu/\gamma_\nu}}}}+\beta_i,\\ {{dx_i}\over {dt}}&=v_iy_i-\tau_ix_i,\quad i=1, 2, \end{aligned} NEWLINE\]NEWLINE where \(\nu=2\) if \(i=1\) and \(\nu=1\) if \(i=2\), \(x_1\) and \(x_2\) denote the concentrations of the transcription factors \(T\)-bet and GATA-3, respectively, \(y_1\) and \(y_2\) are their respective mRNA concentrations, \(\beta_i\) is a constant basal rate of mRNA synthesis, the parameter \(\gamma_i\) is the value of \(x_i\) at which the ratio of production of \(y_i\), due to the combined auto-activation and cytokine signaling is halved, \(\sigma_i{{S_i}\over {\rho_i+S_i}}\) denotes the contribution of combined cytokine signaling to the rate of growth in \(y_i\), the term \({1\over {1+x_l/\gamma_l}}\) is the cross-inhibition between \(y_1\) and \(y_2\) occurring at both the auto-activation level and the cytokine signaling level, and \(\alpha_i\), \(\mu_i\), \(v_i\), \(\tau_i\) and \(\sigma_i\) are parameters.NEWLINENEWLINEThe authors derive conditions on the parameters under which the gene expressions in the \(T\)-cell population aggregate at one, two or four points which connect to various cell differentiation scenarios.

Recommendations

Cites work

Cited in

(3)

This page was built for publication: Asymptotic limit in a cell differentiation model with consideration of transcription

Report a bug (only for logged in users!)Click here to report a bug for this page (MaRDI item Q414831)