Stochastic model for cell polarity

DOI10.1214/11-AAP788zbMATH Open1242.92021arXiv1003.1404OpenAlexW3100481103MaRDI QIDQ417085FDOQ417085

Authors: Ankit Gupta 

Publication date: 13 May 2012

Published in: The Annals of Applied Probability (Search for Journal in Brave)

Abstract: Cell polarity refers to the spatial asymmetry of molecules on the cell membrane. Altschuler, Angenent, Wang and Wu have proposed a stochastic model for studying the emergence of polarity in the presence of feedback between molecules. We analyze their model further by representing it as a model of an evolving population with interacting individuals. Under a suitable scaling of parameters, we show that in the infinite population limit we get a Fleming--Viot process. Using well-known results for such processes, we establish that cell polarity is exhibited by the model and also study its dependence on the biological parameters of the model.

Full work available at URL: https://arxiv.org/abs/1003.1404

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zbMATH Keywords

spatial clusteringDonnelly-KurtzFleming-Viotparticle representation

Mathematics Subject Classification ID

Random measures (60G57) Cell biology (92C37) Superprocesses (60J68)

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Cited In (6)

• Modelling and analysis of planar cell polarity
• Stochastic pattern formation and spontaneous polarisation: the linear noise approximation and beyond
• On stochastic spatial patterns and neuronal polarity
• Incomplete penetrance: the role of stochasticity in developmental cell colonization
• Stochastic models for cell motion and taxis
• Stochastic Active-Transport Model of Cell Polarization

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