scientific article; zbMATH DE number 1222379

MaRDI QIDQ4217899zbMATH OpenFDO

Authors H. I. Patel

Publication date 27 April 1999

zbMATH Keywords

mixed effects modelpredictive powerprojected probabilitiessample size for phase III studies

Mathematics Subject Classification ID

Applications of statistics to biology and medical sciences; meta analysis (62P10)

Recommendations

• Using pilot study information to increase efficiency in clinical trials
• Robust meta‐analytic‐predictive priors in clinical trials with historical control information
• Dynamic borrowing through empirical power priors that control type I error
• Hierarchical commensurate and power prior models for adaptive incorporation of historical information in clinical trials
• Confirmatory clinical trials with an adaptive design

Cited in

(4)

• Meta-analytic-predictive use of historical variance data for the design and analysis of clinical trials
• Using pilot study information to increase efficiency in clinical trials
• Power gains by using external information in clinical trials are typically not possible when requiring strict type I error control
• Sample size calculation for studies comparing binary outcomes using historical controls

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