scientific article; zbMATH DE number 1302429
The title is misleading. The authors are mainly concerned with the modelling of biological systems in which `signal' and `transfer' delays occur naturally. The objective of the chosen approach is to devise a mathematical model, consisting of linear ODEs with constant coefficients in which delays have been ``cleverly eliminated. -- The preliminary ``physical step is an interlinked compartmentalization, and the main step, the replacement of the ODE-system with delays by an `equivalent' one of higher-order without delays. The latter is easy to `study' by means of standard computer methods. It is, however, very debatable whether this ``doctinal approach permits a more profound understanding of biological processes. Moreover, the replacement of an ODE-system with delays by one of a higher (finite) order without delays is not mathematically justified. Physically this approach has no provision for phenomena such as: dependence of the effect of a drug on the time of its administration, non-instantaneous adverse drug reactions, aftereffects of physical and mental traumas, incubation time of infections, and so on. For the entire collection see [Zbl 0901.00038].
- Qualitative theory of compartmental systems with lags.
- scientific article; zbMATH DE number 3880484
- Distributed delay differential equation representations of cyclic differential equations
- An analytical solution for a class of delay-differential equations in pharmacokinetic compartment modeling
- scientific article; zbMATH DE number 194949
- Qualitative theory of compartmental systems with lags.
- Building a structured model of a complex pharmacokinetic system with time delays
- Observations on evolutionary models with (or without) time lag, and on problematical paradigms
- Effects of drugs reabsorption time delays for a pharmacokinetics model in humans
- scientific article; zbMATH DE number 3880484 (Why is no real title available?)
- Distributed delay differential equation representations of cyclic differential equations
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