Effects of drugs reabsorption time delays for a pharmacokinetics model in humans

DOI10.1155/2021/3439887MaRDI QIDQ2669948zbMATH OpenOpenAlexFDO

Authors Adamu Shitu Hassan, Justin Manango W. Munganga

Publication date 9 March 2022

Published in Journal of Applied Mathematics (Search for Journal in Brave)

Copyright license Creative Commons Attribution 4.0 International

Full work available at URL https://doi.org/10.1155/2021/3439887

Mathematics Subject Classification ID

Stability theory of functional-differential equations (34K20) Qualitative investigation and simulation of models involving functional-differential equations (34K60) Kinetics in biochemical problems (pharmacokinetics, enzyme kinetics, etc.) (92C45)

Review text

Summary: A three-compartmental delay model is formulated to describe the pharmacokinetics of drugs subjected to both intravenous and oral doses with reabsorptions by the central compartment. Model dynamics are analyzed rigorously, and two equilibrium points are obtained to be locally asymptotically stable under certain conditions. Time delays used as lags in reabsorption of drugs by central compartment from other two compartments caused rebounds or peaks and fluctuations in the time profiles for amounts of drug in all the compartments. Sensitivity analysis revealed that elimination rates decrease the amounts in all compartments. Furthermore, reabsorption rates cause superimposition at the initial phases of the drug amount profiles; subsequently, the quantities decrease in compartment one and increase in compartments two and three, respectively.

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