Fixation probability for competing selective sweeps

DOI10.1214/EJP.V17-1954zbMATH Open1242.92048arXiv0812.0104OpenAlexW2157646838WikidataQ60500161 ScholiaQ60500161MaRDI QIDQ428648FDOQ428648

Authors: Charles Cuthbertson, Alison Etheridge, Feng Yu 

Publication date: 22 June 2012

Published in: Electronic Journal of Probability (Search for Journal in Brave)

Abstract: We consider a biological population in which a beneficial mutation is undergoing a selective sweep when a second beneficial mutation arises at a linked locus and we investigate the probability that both mutations will eventually fix in the population. Previous work has dealt with the case where the second mutation to arise confers a smaller benefit than the first. In that case population size plays almost no role. Here we consider the opposite case and observe that, by contrast, the probability of both mutations fixing can be heavily dependent on population size. Indeed the key parameter is $hoN$, the product of the population size and the recombination rate between the two selected loci. If $hoN$ is small, the probability that both mutations fix can be reduced through interference to almost zero while for large $hoN$ the mutations barely influence one another. The main rigorous result is a method for calculating the fixation probability of a double mutant in the large population limit.

Full work available at URL: https://arxiv.org/abs/0812.0104

Recommendations

• The fixation probability of two competing beneficial mutations
• The fixation probability and time for a doubly beneficial mutant
• Competing selective sweeps
• Fixation of beneficial mutations in the presence of epistatic interactions
• Effect of epistasis and linkage on fixation probability in three-locus models: an ancestral recombination-selection graph approach

zbMATH Keywords

fixation probabilitydouble mutant

Mathematics Subject Classification ID

Applications of Markov chains and discrete-time Markov processes on general state spaces (social mobility, learning theory, industrial processes, etc.) (60J20) Genetics and epigenetics (92D10) Problems related to evolution (92D15)

Cited In (17)

• Fixation of beneficial mutations in the presence of epistatic interactions
• Fixation probability of a nonmutator in a large population of asexual mutators
• The effect of recombination on the speed of evolution
• Effect of epistasis and linkage on fixation probability in three-locus models: an ancestral recombination-selection graph approach
• Selective sweep and the size of the hitchhiking set
• Fixation probabilities of additive alleles in diploid populations
• An eco-evolutionary approach of adaptation and recombination in a large population of varying size
• Extinction and fixation times with dominance and inbreeding
• Role of epistasis on the fixation probability of a non-mutator in an adapted asexual population
• Fixation probability in a two-locus intersexual selection model
• Haldane's formula in Cannings models: the case of moderately strong selection
• The probability of fixation of a single mutant in an exchangeable selection model
• Population structure and the rate of evolution
• Asymptotic behavior of the rate of adaptation
• Competing selective sweeps
• The fixation probability and time for a doubly beneficial mutant
• The fixation probability of two competing beneficial mutations

This page was built for publication: Fixation probability for competing selective sweeps

Report a bug (only for logged in users!)Click here to report a bug for this page (MaRDI item Q428648)