Modelling the effect of gap junctions on tissue-level cardiac electrophysiology
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Publication:458677
DOI10.1007/S11538-013-9927-1zbMATH Open1297.92018arXiv1208.3848OpenAlexW2962910343WikidataQ43554806 ScholiaQ43554806MaRDI QIDQ458677FDOQ458677
Authors: Doug Bruce, Pras Pathmanathan, Jonathan P. Whiteley 
Publication date: 8 October 2014
Published in: Bulletin of Mathematical Biology (Search for Journal in Brave)
Abstract: When modelling tissue-level cardiac electrophysiology, continuum approximations to the discrete cell-level equations are used to maintain computational tractability. One of the most commonly used models is represented by the bidomain equations, the derivation of which relies on a homogenisation technique to construct a suitable approximation to the discrete model. This derivation does not explicitly account for the presence of gap junctions connecting one cell to another. It has been seen experimentally [Rohr, Cardiovasc. Res. 2004] that these gap junctions have a marked effect on the propagation of the action potential, specifically as the upstroke of the wave passes through the gap junction. In this paper we explicitly include gap junctions in a both a 2D discrete model of cardiac electrophysiology, and the corresponding continuum model, on a simplified cell geometry. Using these models we compare the results of simulations using both continuum and discrete systems. We see that the form of the action potential as it passes through gap junctions cannot be replicated using a continuum model, and that the underlying propagation speed of the action potential ceases to match up between models when gap junctions are introduced. In addition, the results of the discrete simulations match the characteristics of those shown in Rohr 2004. From this, we suggest that a hybrid model -- a discrete system following the upstroke of the action potential, and a continuum system elsewhere -- may give a more accurate description of cardiac electrophysiology.
Full work available at URL: https://arxiv.org/abs/1208.3848
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Cites Work
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Cited In (10)
- Modelling changes in transmural propagation and susceptibility to arrhythmia induced by volatile anaesthetics in ventricular tissue
- Homogenization of an electrophysiological model for a strand of cardiac myocytes with gap-junctional and electric-field coupling
- Modeling triggered cardiac activity: An analysis of the interactions between potassium blockade, rhythm pauses, and cellular coupling
- Microscopic tridomain model of electrical activity in the heart with dynamical gap junctions. I: Modeling and well-posedness
- Modeling the effect of ion channel inhibitors on the functioning of the cardiac sinoatrial node cells
- PROGRESS AND GAPS IN UNDERSTANDING THE ELECTROPHYSIOLOGICAL PROPERTIES OF MORPHOLOGICALLY NORMAL CELLS FROM THE CARDIAC ATRIOVENTRICULAR NODE
- Bond graph modelling of the cardiac action potential: implications for drift and non-unique steady states
- Interpreting voltage-sensitivity of gap junctions as a mechanism of cardiac memory
- Minimal model for human ventricular action potentials in tissue
- Representation of multiple cellular phenotypes within tissue-level simulations of cardiac electrophysiology
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