Microscopic tridomain model of electrical activity in the heart with dynamical gap junctions. I: Modeling and well-posedness

DOI10.1007/S10440-022-00498-7zbMATH Open1490.92016arXiv2205.15605OpenAlexW4281622429MaRDI QIDQ2145679FDOQ2145679

Mazen Saad, Mostafa Bendahmane, Raafat Talhouk, Fakhrielddine Bader

Publication date: 17 June 2022

Published in: Acta Applicandae Mathematicae (Search for Journal in Brave)

Abstract: We present a novel microscopic tridomain model describing the electrical activity in cardiac tissue with dynamical gap junctions. The microscopic tridomain system consists of three PDEs modeling the tissue electrical conduction in the intra-and extra-cellular domains, supplemented by a nonlinear ODE system for the dynamics of the ion channels and the gap junctions. We establish the global existence and uniqueness of the weak solutions to our microscopic tridomain model. The global existence of solution, which constitutes the main result of this paper, is proved by means of an approximate non-degenerate system, the Faedo-Galerkin method, and an appropriate compactness argument.

Full work available at URL: https://arxiv.org/abs/2205.15605

Recommendations

• Microscopic tridomain model of electrical activity in the heart with dynamical gap junctions. Part 2 – Derivation of the macroscopic tridomain model by unfolding homogenization method
• Modelling the effect of gap junctions on tissue-level cardiac electrophysiology
• Homogenization of an electrophysiological model for a strand of cardiac myocytes with gap-junctional and electric-field coupling
• Reaction-diffusion systems for the macroscopic bidomain model of the cardiac electric field
• Reaction–diffusion systems for the microscopic cellular model of the cardiac electric field
• scientific article; zbMATH DE number 5587405
• Derivation of a new macroscopic bidomain model including three scales for the electrical activity of cardiac tissue
• Towards the modeling of the Purkinje/myocardium coupled problem: a well-posedness analysis
• scientific article; zbMATH DE number 1944198
• Multiscale Modeling for the Bioelectric Activity of the Heart

zbMATH Keywords

global existenceuniquenessweak solutiongap junctionstridomain modelcardiac electro-physiology

Mathematics Subject Classification ID

Physiology (general) (92C30) PDEs in connection with biology, chemistry and other natural sciences (35Q92) Finite element, Rayleigh-Ritz and Galerkin methods for initial value and initial-boundary value problems involving PDEs (65M60) Computational methods for problems pertaining to biology (92-08)

Cites Work

• Mathematical tools for the study of the incompressible Navier-Stokes equations and related models
• A two-current model for the dynamics of cardiac membrane
• Title not available (Why is that?)
• Mathematical physiology
• The Cahn-Hilliard equation with dynamic boundary conditions.
• Title not available (Why is that?)
• Analysis of a class of degenerate reaction-diffusion systems and the bidomain model of cardiac tissue
• Existence and uniqueness of the solution for the bidomain model used in cardiac electrophysiology
• Multiscale Modeling for the Bioelectric Activity of the Heart
• A Coupled System of PDEs and ODEs Arising in Electrocardiograms Modeling
• Reaction-diffusion systems for the macroscopic bidomain model of the cardiac electric field
• Well-posedness and long time behavior of the non-isothermal viscous Cahn-Hilliard equation with dynamic boundary conditions
• The Cardiac bidomain model and homogenization
• Derivation of a new macroscopic bidomain model including three scales for the electrical activity of cardiac tissue
• Unfolding homogenization method applied to physiological and phenomenological bidomain models in electrocardiology
• Three scale unfolding homogenization method applied to cardiac bidomain model

Cited In (5)

• Title not available (Why is that?)
• Microscopic tridomain model of electrical activity in the heart with dynamical gap junctions. Part 2 – Derivation of the macroscopic tridomain model by unfolding homogenization method
• Convergence Analysis of BDDC Preconditioners for Composite DG Discretizations of the Cardiac Cell-By-Cell Model
• Cellular communication among smooth muscle cells: the role of membrane potential via connexins
• A Coupled System of PDEs and ODEs Arising in Electrocardiograms Modeling

This page was built for publication: Microscopic tridomain model of electrical activity in the heart with dynamical gap junctions. I: Modeling and well-posedness

Report a bug (only for logged in users!)Click here to report a bug for this page (MaRDI item Q2145679)