Microscopic tridomain model of electrical activity in the heart with dynamical gap junctions. I: Modeling and well-posedness

DOI10.1007/S10440-022-00498-7MaRDI QIDQ2145679zbMATHOpenAlexFDO

Authors Fakhrielddine Bader, Mostafa Bendahmane, Mazen Saad, Raafat Talhouk

Publication date 17 June 2022

Published in Acta Applicandae Mathematicae (Search for Journal in Brave)

Full work available at URL https://arxiv.org/abs/2205.15605

zbMATH Keywords

global existenceuniquenessweak solutiongap junctionstridomain modelcardiac electro-physiology

Mathematics Subject Classification ID

Physiology (general) (92C30) PDEs in connection with biology, chemistry and other natural sciences (35Q92) Finite element, Rayleigh-Ritz and Galerkin methods for initial value and initial-boundary value problems involving PDEs (65M60) Computational methods for problems pertaining to biology (92-08)

Abstract: We present a novel microscopic tridomain model describing the electrical activity in cardiac tissue with dynamical gap junctions. The microscopic tridomain system consists of three PDEs modeling the tissue electrical conduction in the intra-and extra-cellular domains, supplemented by a nonlinear ODE system for the dynamics of the ion channels and the gap junctions. We establish the global existence and uniqueness of the weak solutions to our microscopic tridomain model. The global existence of solution, which constitutes the main result of this paper, is proved by means of an approximate non-degenerate system, the Faedo-Galerkin method, and an appropriate compactness argument.

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Cites work

• scientific article; zbMATH DE number 1944198 (Why is no real title available?)
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• Three scale unfolding homogenization method applied to cardiac bidomain model
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• Well-posedness and long time behavior of the non-isothermal viscous Cahn-Hilliard equation with dynamic boundary conditions

Cited in

(8)

• Microscopic tridomain model of electrical activity in the heart with dynamical gap junctions. Part 2 – Derivation of the macroscopic tridomain model by unfolding homogenization method
• Reaction–diffusion systems for the microscopic cellular model of the cardiac electric field
• Well-posedness for a modified bidomain model describing bioelectric activity in damaged heart tissues
• scientific article; zbMATH DE number 1944198 (Why is no real title available?)
• A Coupled System of PDEs and ODEs Arising in Electrocardiograms Modeling
• Convergence Analysis of BDDC Preconditioners for Composite DG Discretizations of the Cardiac Cell-By-Cell Model
• Modelling the effect of gap junctions on tissue-level cardiac electrophysiology
• Cellular communication among smooth muscle cells: the role of membrane potential via connexins

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