Evaluating the accuracy of small p-values in genetic association studies using Edgeworth expansions

DOI10.1111/SJOS.12283MaRDI QIDQ4637089zbMATH OpenOpenAlexFDO

Authors Gang Zheng, Jinghong Xiong, Qizhai Li, Jinfeng Xu, Ao Yuan, Joe L. Gastwirth

Publication date 17 April 2018

Published in Scandinavian Journal of Statistics (Search for Journal in Brave)

Full work available at URL https://doi.org/10.1111/sjos.12283

zbMATH Keywords

asymptotic normal distributionBonferroni correctionchi-squared testEdgeworth expansionmaximin efficiency robust test (MERT)maximum likelihood estimatenuisance parameter

Mathematics Subject Classification ID

Asymptotic distribution theory in statistics (62E20) Hypothesis testing in multivariate analysis (62H15) Applications of statistics to biology and medical sciences; meta analysis (62P10) Protein sequences, DNA sequences (92D20)

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Cites work

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Cited in

(3)

• Robust methods to detect disease-genotype association in genetic association studies: calculate \(p\)-values using exact conditional enumeration instead of simulated permutations or asymptotic approximations
• High-order asymptotic approximations for improved inference under exceptionally low false positive error rates
• How accurate are the extremely small \(P\)-values used in genomic research: an evaluation of numerical libraries

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