Robust methods to detect disease-genotype association in genetic association studies: calculate \(p\)-values using exact conditional enumeration instead of simulated permutations or asymptotic approximations

DOI10.1515/sagmb-2013-0084zbMath1302.92074arXiv1307.7536OpenAlexW3106510470WikidataQ45914058 ScholiaQ45914058MaRDI QIDQ482819

Øyvind Bakke, Mette Langaas

Publication date: 6 January 2015

Published in: Statistical Applications in Genetics and Molecular Biology (Search for Journal in Brave)

Full work available at URL: https://arxiv.org/abs/1307.7536

zbMATH Keywords

permutationcase-control studycontingency tableexact testsgenetic models

Mathematics Subject Classification ID

Applications of statistics to biology and medical sciences; meta analysis (62P10) General biostatistics (92B15) Genetics and epigenetics (92D10)

Related Items (1)

Simultaneous Bayesian analysis of contingency tables in genetic association studies

Uses Software

• Rassoc
• MaXact
• Eigenstrat

Cites Work

• A Network Algorithm for Performing Fisher's Exact Test in r × c Contingency Tables
• Permutation \(p\)-values should never be zero: calculating exact \(p\)-values when permutations are randomly drawn
• A Cautionary Note on Exact Unconditional Inference for a Difference between Two Independent Binomial Proportions
• The Use of Maximin Efficiency Robust Tests in Combining Contingency Tables and Survival Analysis
• On the Robustness of Combined Tests for Trends in Proportions
• Some Surprising Results about Covariate Adjustment in Logistic Regression Models
• The Fisher, Neyman-Pearson Theories of Testing Hypotheses: One Theory or Two?
• From Genotypes to Genes: Doubling the Sample Size
• Genomic Control for Association Studies
• Choice of Scores in Trend Tests for Case-Control Studies of Candidate-Gene Associations
• Some Methods for Strengthening the Common χ 2 Tests
• A Robust Genome‐Wide Scan Statistic of the Wellcome Trust Case–Control Consortium
• A Note on Comparing the Power of Test Statistics at Low Significance Levels
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