Analysis of symmetries in models of multi-strain infections

DOI10.1007/S00285-013-0740-0zbMATH Open1307.92336arXiv1311.4808OpenAlexW1984730916WikidataQ44091338 ScholiaQ44091338MaRDI QIDQ476792FDOQ476792

Authors: K. B. Blyuss 

Publication date: 2 December 2014

Published in: Journal of Mathematical Biology (Search for Journal in Brave)

Abstract: In mathematical studies of the dynamics of multi-strain diseases caused by antigenically diverse pathogens, there is a substantial interest in analytical insights. Using the example of a generic model of multi-strain diseases with cross-immunity between strains, we show that a significant understanding of the stability of steady states and possible dynamical behaviours can be achieved when the symmetry of interactions between strains is taken into account. Techniques of equivariant bifurcation theory allow one to identify the type of possible symmetry-breaking Hopf bifurcation, as well as to classify different periodic solutions in terms of their spatial and temporal symmetries. The approach is also illustrated on other models of multi-strain diseases, where the same methodology provides a systematic understanding of bifurcation scenarios and periodic behaviours. The results of the analysis are quite generic, and have wider implications for understanding the dynamics of a large class of models of multi-strain diseases.

Full work available at URL: https://arxiv.org/abs/1311.4808

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zbMATH Keywords

symmetryequivariant bifurcation theorymulti-strain disease

Mathematics Subject Classification ID

Epidemiology (92D30) Dynamical aspects of symmetries, equivariant bifurcation theory (37G40)

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Cited In (10)

• Bifurcation, stability, and cluster formation of multi-strain infection models
• Symmetry in a multi-strain epidemiological model with distributed delay as a general cross-protection period and disease enhancement factor
• Symmetry, Hopf bifurcation, and the emergence of cluster solutions in time delayed neural networks
• Characterizing the symmetric equilibrium of multi-strain host-pathogen systems in the presence of cross immunity
• The effects of symmetry on the dynamics of antigenic variation
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• An age-structured multi-strain epidemic model for antigenically diverse infectious diseases: a multi-locus framework
• Chimera states in multi-strain epidemic models with temporary immunity
• Mathematical analysis of a multiple strain, multi-locus-allele system for antigenically variable infectious diseases revisited
• Synchrony-breaking Hopf bifurcation in a model of antigenic variation

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