Effect of intracellular diffusion on current-voltage curves in potassium channels
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Publication:478676
DOI10.3934/DCDSB.2014.19.1837zbMATH Open1327.92015arXiv1206.3148OpenAlexW2963344147MaRDI QIDQ478676FDOQ478676
Authors: Daniele Andreucci, Dario Bellaveglia, Silvia Marconi, Emilio N. M. Cirillo 
Publication date: 4 December 2014
Published in: Discrete and Continuous Dynamical Systems. Series B (Search for Journal in Brave)
Abstract: We study the effect of intracellular ion diffusion on ionic currents permeating through the cell membrane. Ion flux across the cell membrane is mediated by special proteins forming specific channels. The structure of potassium channels have been widely studied in recent years with remarkable results: very precise measurements of the true current across a single channel are now available. Nevertheless, a complete understanding of the behavior of the channel is still lacking, though molecular dynamics and kinetic models have provided partial insights. In this paper we demonstrate, by analyzing the KcsA current-voltage currents via a suitable lattice model, that intracellular diffusion plays a crucial role in the permeation phenomenon. The interplay between the selectivity filter behavior and the ion diffusion in the intracellular side allows a full explanation of the current-voltage curves.
Full work available at URL: https://arxiv.org/abs/1206.3148
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Cites Work
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