Effect of intracellular diffusion on current-voltage curves in potassium channels
From MaRDI portal
(Redirected from Publication:478676)
Abstract: We study the effect of intracellular ion diffusion on ionic currents permeating through the cell membrane. Ion flux across the cell membrane is mediated by special proteins forming specific channels. The structure of potassium channels have been widely studied in recent years with remarkable results: very precise measurements of the true current across a single channel are now available. Nevertheless, a complete understanding of the behavior of the channel is still lacking, though molecular dynamics and kinetic models have provided partial insights. In this paper we demonstrate, by analyzing the KcsA current-voltage currents via a suitable lattice model, that intracellular diffusion plays a crucial role in the permeation phenomenon. The interplay between the selectivity filter behavior and the ion diffusion in the intracellular side allows a full explanation of the current-voltage curves.
Recommendations
- The physical basis of ion channel kinetic: the importance of dynamics
- Electrodiffusion Model of Rectangular Current Pulses in Ionic Channels of Cellular Membranes
- Finite ion size effects on ionic flows via Poisson-Nernst-Planck systems: higher order contributions
- Electrodiffusion model simulation of the potassium channel
- Normal mode dynamics of voltage-gated \(\mathrm{K}^+\) channels: gating principle, opening mechanism, and inhibition
Cites work
Cited in
(21)- Investigating the potassium interactions with the palytoxin induced channels in Na^+/K^+ pump
- Receptors and functional linkage in membrane permeability: A quantum mechanical model
- Residence time estimates for asymmetric simple exclusion dynamics on strips
- Voltage and frequency dependence of prestin-associated charge transfer
- Dynamics of pedestrians in regions with no visibility -- a lattice model without exclusion
- Normal mode dynamics of voltage-gated \(\mathrm{K}^+\) channels: gating principle, opening mechanism, and inhibition
- Electrodiffusion near an ion channel and the effect of mobile buffer
- Singular kernel problems in materials with memory
- Voltage-sensitive ion channels. Biophysics of molecular excitability
- scientific article; zbMATH DE number 1008689 (Why is no real title available?)
- Electrodiffusion Model of Rectangular Current Pulses in Ionic Channels of Cellular Membranes
- Free energy dissipation of the spontaneous gating of a single voltage-gated potassium channel
- Free to move or trapped in your group: mathematical modeling of information overload and coordination in crowded populations
- A model for enhanced and selective transport through biological membranes with alternating pores
- Computational model of electrode-induced microenvironmental effects on ph measurements near a cell membrane
- MD study of solution concentrations on ion distribution in a nanopore-based device inspired from red blood cells
- How interactions control molecular transport in channels
- The physical basis of ion channel kinetic: the importance of dynamics
- Collective behavior of membrane channels: electro-physiological studies on gap junctions
- Diffusion through a cluster of small windows and flux regulation in microdomains
- On the sodium concentration diffusion with three-dimensional extracellular stimulation
This page was built for publication: Effect of intracellular diffusion on current-voltage curves in potassium channels
Report a bug (only for logged in users!)Click here to report a bug for this page (MaRDI item Q478676)
