Analyzing Randomized Dose Finding Studies with a Primary and a Secondary Endpoint

DOI10.1081/BIP-120019273zbMATH Open1181.62180OpenAlexW1987386643WikidataQ73348132 ScholiaQ73348132MaRDI QIDQ4803389FDOQ4803389

Authors: Ludwig A. Hothorn, Gernot Wassmer 

Publication date: 2 April 2003

Published in: Journal of Biopharmaceutical Statistics (Search for Journal in Brave)

Full work available at URL: https://doi.org/10.1081/bip-120019273

Recommendations

• A dose finding procedure based on the multivariate likelihood ratio test
• Simultaneous identifications of the minimum effective dose in each of several groups
• NONPARAMETRIC IDENTIFICATION OF THE MINIMUM EFFECTIVE DOSE FOR RANDOMIZED BLOCK DESIGNS
• Multiple testing for dose finding
• Nonparametric Multiple Test Procedures for Dose Finding

Mathematics Subject Classification ID

Applications of statistics to biology and medical sciences; meta analysis (62P10) Medical applications (general) (92C50)

Cites Work

• Multiple Test Procedures for Identifying the Minimum Effective and Maximum Safe Doses of a Drug
• Some new multiple-test procedures for dose finding
• NONPARAMETRIC STEP-DOWN TEST PROCEDURES FOR FINDING MINIMUM EFFECTIVE DOSE

Cited In (4)

• Protocol Designed Subgroup Analyses in Multiarmed Clinical Trials: Multiplicity Aspects
• A Cautionary Note on Design Implications when the Primary Analysis is a Stratified Analysis of a Binary Endpoint
• Two‐Stage Designs for Dose‐Finding Trials with a Biologic Endpoint Using Stepwise Tests
• Retrospective Analysis of Sequential Dose‐Finding Designs

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