Blends of statistical designs for dose-response studies1

DOI10.1080/03610929408831259MaRDI QIDQ4843732zbMATH OpenOpenAlexFDO

Authors A. S. Hedayat, G. Y. H. Chi, K. Mahjoob

Publication date 17 August 1995

Published in Communications in Statistics: Theory and Methods (Search for Journal in Brave)

Full work available at URL https://doi.org/10.1080/03610929408831259

zbMATH Keywords

combination drugconfirmatory trialdose-responsedose-titrationfactorial designforced titrationparallel-group designpopulation mean-dose response curverepeated measurements designsupportive trialvariable treatment duration

Mathematics Subject Classification ID

Statistics (62-XX)

Recommendations

• Optimal designs for dose-finding studies
• On the combination of \(c\)- and \(D\)-optimal designs: general approaches and applications in dose-response studies
• Optimal 3×3 factorial and 3-ray designs for drug interaction experiments with dichotomous responses
• Experimental designs for drug combination studies
• Sequential design for binary dose-response experiments

Cites work

• Biostatistical Collaboration in Medical Research
• Comparison of treatments in a combination therapy trial
• Optimal designs for comparing test treatments with controls. With comments and a rejoinder by the authors
• Optimal two-period repeated measurements designs
• Repeated measurements designs, II
• Testing for the Existence of a Desirable Dose Combination

Cited in

(2)

• Application of response surface methodology and factorial designs to clinical trials for drug combination development
• On some statistical methods for analysis of combination drug studies^∗

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