Evaluation and Estimation of Various Markov Models with Applications to Membrane Channel Kinetics

DOI10.1002/BIMJ.4710370104MaRDI QIDQ4865212zbMATH OpenOpenAlexFDO

Authors Graham Pulford, J. C. Gallant, R. A. Kennedy, Shin-Ho Chung

Publication date 7 March 1996

Published in Biometrical Journal (Search for Journal in Brave)

Full work available at URL https://doi.org/10.1002/bimj.4710370104

zbMATH Keywords

aggregated Markov modelschannel dynamicscoupled Markov modelsdigital signal processing strategydiscrete-time hidden Markov modelinitial state distributionion channelsmaximum likelihood estimationmaximum likelihood modelmembrane channel kineticsmodel evaluationnoise variancesample of noisy datasemi-Markov modelssimulationsstate levelstransition probabilities

Mathematics Subject Classification ID

Markov processes: estimation; hidden Markov models (62M05) Applications of statistics to biology and medical sciences; meta analysis (62P10) Physiology (general) (92C30)

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Cites work

• scientific article; zbMATH DE number 3148886 (Why is no real title available?)
• scientific article; zbMATH DE number 3997615 (Why is no real title available?)
• Regenerative stochastic processes
• Statistical analysis of finite mixture distributions

Cited in

(13)

• Investigating the underlying Markovian dynamics of ECG rhythms by information flow
• Coupled Markov chain model: Characterization of membrane channel currents with multiple conductance sublevels as partially coupled elementary pores
• Adaptive-step methods for Markov-based membrane models
• Finite sample properties of the maximum likelihood estimator and of likelihood ratio tests in hidden Markov models
• scientific article; zbMATH DE number 987967 (Why is no real title available?)
• Markov models for ion channels: versatility versus identifiability and speed
• Continuous-time Markov chains in a random environment, with applications to ion channel modelling
• scientific article; zbMATH DE number 1487753 (Why is no real title available?)
• A Markov Chain Channel Model for Active Transport Molecular Communication
• scientific article; zbMATH DE number 832723 (Why is no real title available?)
• Sensitivity and convergence of uniformly ergodic Markov chains
• Identification of individual channel kinetics from recordings containing many identical channels
• Model selection and parameter estimation for ion channel recordings with an application to the \(K^{+}\) outward-rectifier in barley leaf

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