Mathematics of the NFAT Signaling Pathway

DOI10.1137/120866488MaRDI QIDQ4904532zbMATHOpenAlexFDO

Authors Alan D. Rendall

Publication date 30 January 2013

Published in SIAM Journal on Applied Dynamical Systems (Search for Journal in Brave)

Full work available at URL https://arxiv.org/abs/1201.1094

zbMATH Keywords

immunologychemical reaction network theorysignaling pathway

Mathematics Subject Classification ID

Biochemistry, molecular biology (92C40) Dynamical systems in biology (37N25) Stability theory for smooth dynamical systems (37C75) Cell biology (92C37)

Abstract: This paper is a mathematical study of some aspects of the signalling pathway leading to the activation of the transcription factor NFAT (nuclear factor of activated T cells). Activation takes place by dephosphorylation at multiple sites. This has been modelled by Salazar and H"ofer using a large system of ordinary differential equations depending on many parameters. With the help of chemical reaction network theory we show that for any choice of the parameters this system has a unique stationary solution for each value of the conserved quantity given by the total amount of NFAT and that all solutions converge to this stationary solution at late times. The dephosphorylation is carried out by calcineurin, which in turn is activated by a rise in calcium concentration. We study the way in which the dynamics of the calcium concentration influences NFAT activation, an issue also considered by Salazar and H"ofer with the help of a model arising from work of Somogyi and Stucki. Criteria are obtained for convergence to equilibrium of solutions of the model for the calcium concentration.

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