Panel forum on multiple comparison procedures: A commentary from a complex trial design and analysis plan

DOI10.1002/BIMJ.201200047MaRDI QIDQ4921947zbMATHOpenAlexWikidataFDO

Authors Sue-Jane Wang, Frank Bretz, Alex Dmitrienko, Jason C. Hsu, H. M. James Hung, Mohammad Huque, Gary G. Koch

Publication date 28 May 2013

Published in Biometrical Journal (Search for Journal in Brave)

Full work available at URL https://doi.org/10.1002/bimj.201200047

zbMATH Keywords

correlationalpha propagationdecision path partition testDose-endpoint pairFisher's protected least significance differencemultiplicity-at-combined-trial level (or programwise type I error)parallel gatekeepingsingle hierarchical chaintruncated and regular hommel-based gatekeeping

Mathematics Subject Classification ID

Applications of statistics to biology and medical sciences; meta analysis (62P10)

Recommendations

• Multiple comparisons in complex clinical trial designs
• Industry, Government, and Academic Panel Discussion on Multiple Comparisons in a “Real” Phase Three Clinical Trial
• On the behavior of multiple comparison procedures in complex parametric designs
• Multiple analyses in clinical trials. Fundamentals for investigators
• Protocol Designed Subgroup Analyses in Multiarmed Clinical Trials: Multiplicity Aspects
• Multiple testing procedures for analyzing stratified comparative clinical trials using odds ratios

Cites work

• Approximation Theorems of Mathematical Statistics
• Challenges to multiple testing in clinical trials
• Development of gatekeeping strategies in confirmatory clinical trials
• Graphical approaches for multiple comparison procedures using weighted Bonferroni, Simes, or parametric tests
• Permutation Multiple Tests of Binary Features Do Not Uniformly Control Error Rates
• Testing for efficacy in primary and secondary endpoints by partitioning decision paths

Cited in

(3)

• Industry, Government, and Academic Panel Discussion on Multiple Comparisons in a “Real” Phase Three Clinical Trial
• Multiple comparisons in complex clinical trial designs
• Maximum type 1 error rate inflation in multiarmed clinical trials with adaptive interim sample size modifications

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