Development of gatekeeping strategies in confirmatory clinical trials

DOI10.1002/BIMJ.201100036MaRDI QIDQ2889660zbMATHOpenAlexWikidataFDO

Authors Alex Dmitrienko, Brian A. Millen, Thomas Brechenmacher, Gautier Paux

Publication date 8 June 2012

Published in Biometrical Journal (Search for Journal in Brave)

Full work available at URL https://doi.org/10.1002/bimj.201100036

zbMATH Keywords

powermultiple testsfamilywise error rate

Mathematics Subject Classification ID

Applications of statistics to biology and medical sciences; meta analysis (62P10) Medical applications (general) (92C50) Paired and multiple comparisons; multiple testing (62J15)

Recommendations

• General theory of mixture procedures for gatekeeping
• A multiple comparison procedure for hypotheses with gatekeeping structure
• General Multistage Gatekeeping Procedures
• A simple and flexible Holm gatekeeping procedure
• Gatekeeping testing via adaptive alpha allocation

Cites work

• On closed testing procedures with special reference to ordered analysis of variance
• Optimally weighted, fixed sequence and gatekeeper multiple testing procedures
• Some probability inequalities for ordered MTP\(_2\) random variables: a proof of the Simes conjecture
• Testing for efficacy in primary and secondary endpoints by partitioning decision paths
• The Simes Method for Multiple Hypothesis Testing With Positively Dependent Test Statistics

Cited in

(3)

• General theory of mixture procedures for gatekeeping
• A multiple comparison procedure for hypotheses with gatekeeping structure
• Panel forum on multiple comparison procedures: A commentary from a complex trial design and analysis plan

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