Development of gatekeeping strategies in confirmatory clinical trials

DOI10.1002/BIMJ.201100036MaRDI QIDQ2889660zbMATH OpenOpenAlexWikidataFDO

Authors Alex Dmitrienko, Brian A. Millen, Thomas Brechenmacher, Gautier Paux

Publication date 8 June 2012

Published in Biometrical Journal (Search for Journal in Brave)

Full work available at URL https://doi.org/10.1002/bimj.201100036

zbMATH Keywords

familywise error ratemultiple testspower

Mathematics Subject Classification ID

Paired and multiple comparisons; multiple testing (62J15) Applications of statistics to biology and medical sciences; meta analysis (62P10) Medical applications (general) (92C50)

Recommendations

• General theory of mixture procedures for gatekeeping
• A multiple comparison procedure for hypotheses with gatekeeping structure
• General Multistage Gatekeeping Procedures
• A simple and flexible Holm gatekeeping procedure
• Gatekeeping testing via adaptive alpha allocation

Cites work

• On closed testing procedures with special reference to ordered analysis of variance
• Optimally weighted, fixed sequence and gatekeeper multiple testing procedures
• Some probability inequalities for ordered MTP₂ random variables: a proof of the Simes conjecture
• Testing for efficacy in primary and secondary endpoints by partitioning decision paths
• The Simes Method for Multiple Hypothesis Testing With Positively Dependent Test Statistics

Cited in

(8)

• Panel forum on multiple comparison procedures: A commentary from a complex trial design and analysis plan
• General theory of mixture procedures for gatekeeping
• A multiple comparison procedure for hypotheses with gatekeeping structure
• Optimizing the order of hypotheses in serial testing of multiple endpoints in clinical trials
• Traditional multiplicity adjustment methods in clinical trials
• Graphical approaches using a Bonferroni mixture of weighted Simes tests
• Key multiplicity issues in clinical drug development
• Superchain procedures in clinical trials with multiple objectives

This page was built for publication: Development of gatekeeping strategies in confirmatory clinical trials

Report a bug (only for logged in users!)Click here to report a bug for this page (MaRDI item Q2889660)