Synchrony and oscillatory dynamics for a 2-d PDE-ODE model of diffusion-mediated communication between small signaling compartments
From MaRDI portal
Publication:4983537
Abstract: We analyze a class of cell-bulk coupled PDE-ODE models, motivated by quorum and diffusion sensing phenomena in microbial systems, that characterize communication between localized spatially segregated dynamically active signaling compartments that have a permeable boundary. Each cell secretes a signaling chemical into the bulk region at a constant rate and receives a feedback of the bulk chemical from the entire collection of cells. This global feedback, which activates signaling pathways within the cells, modifies the intracellular dynamics according to the external environment. The cell secretion and global feedback are regulated by permeability parameters across the cell membrane. For arbitrary reaction-kinetics within each cell, the method of matched asymptotic expansions is used in the limit of small cell radius to construct steady-state solutions of the PDE-ODE model, and to derive a globally coupled nonlinear matrix eigenvalue problem (GCEP) that characterizes the linear stability properties of the steady-states. In the limit of large bulk diffusivity an asymptotic analysis of the PDE-ODE model leads to a limiting ODE system for the spatial average of the concentration in the bulk region that is coupled to the intracellular dynamics within the cells. Results from the linear stability theory and ODE dynamics are illustrated for Sel'kov reaction-kinetics, where the kinetic parameters are chosen so that each cell is quiescent when uncoupled from the bulk medium. For various specific spatial configurations of cells, the linear stability theory is used to construct phase diagrams in parameter space characterizing where a switch-like emergence of intracellular oscillations can occur through a Hopf bifurcation.
Recommendations
- An asymptotic analysis of a 2-D model of dynamically active compartments coupled by bulk diffusion
- Localised signalling compartments in 2D coupled by a bulk diffusion field: quorum sensing and synchronous oscillations in the well-mixed limit
- Synchronous oscillations for a coupled cell-bulk ODE-PDE model with localized cells on \({\mathbb{R}}^2\)
- A theory of synchrony by coupling through a diffusive chemical signal
- Synchronized oscillatory dynamics for a 1-D model of membrane kinetics coupled by linear bulk diffusion
Cites work
- A mathematical model for quorum sensing in \textit{Pseudomonas aeruginosa}
- A PDE-DDE model for cell polarization in fission yeast
- A theory of synchrony by coupling through a diffusive chemical signal
- An asymptotic analysis of a 2-D model of dynamically active compartments coupled by bulk diffusion
- Approximating the dynamics of communicating cells in a diffusive medium by ODEs -- homogenization with localization
- Cell-cell communication by quorum sensing and dimension-reduction
- Hopf bifurcation in a gene regulatory network model: molecular movement causes oscillations
- scientific article; zbMATH DE number 1749975 (Why is no real title available?)
- scientific article; zbMATH DE number 819507 (Why is no real title available?)
- Individual-based model for quorum sensing with background flow
- NLEVP, a collection of nonlinear eigenvalue problems
- Optimizing the fundamental Neumann eigenvalue for the Laplacian in a domain with small traps
- Oscillatory dynamics for a coupled membrane-bulk diffusion model with Fitzhugh-Nagumo membrane kinetics
- Quorum sensing in populations of spatially extended chaotic oscillators coupled indirectly via a heterogeneous environment
- Selection of spatiotemporal patterns in arrays of spatially distributed oscillators indirectly coupled via a diffusive environment
- Spatio-temporal models of synthetic genetic oscillators
- Spots, traps, and patches: asymptotic analysis of localized solutions to some linear and nonlinear diffusive systems
- Summing Logarithmic Expansions for Singularly Perturbed Eigenvalue Problems
- Synchronized oscillatory dynamics for a 1-D model of membrane kinetics coupled by linear bulk diffusion
- The nonlinear eigenvalue problem
- The role of trans-membrane signal transduction in Turing-type cellular pattern formation
- Weakly nonlinear theory for oscillatory dynamics in a one-dimensional PDE-ODE model of membrane dynamics coupled by a bulk diffusion field
Cited in
(13)- Dynamically active compartments coupled by a stochastically gated gap junction
- A theory of synchrony by coupling through a diffusive chemical signal
- Synchronous oscillations for a coupled cell-bulk ODE-PDE model with localized cells on \({\mathbb{R}}^2\)
- Quorum-sensing induced transitions between bistable steady-states for a cell-bulk ODE-PDE model with lux intracellular kinetics
- An asymptotic analysis of a 2-D model of dynamically active compartments coupled by bulk diffusion
- Approximating the dynamics of communicating cells in a diffusive medium by ODEs -- homogenization with localization
- Localised signalling compartments in 2D coupled by a bulk diffusion field: quorum sensing and synchronous oscillations in the well-mixed limit
- Fundamental Limits of Efficacy of Intercellular Communication by Diffusion
- Cellular diffusion processes in singularly perturbed domains
- Oscillatory instabilities in dynamically active signaling compartments coupled via bulk diffusion in a 3-D spherical domain
- The emergence of spatial patterns for compartmental reaction kinetics coupled by two bulk diffusing species with comparable diffusivities
- Synchronized memory-dependent intracellular oscillations for a cell-bulk ODE-PDE model in \(\mathbb{R}^2\)
- Iterative learning control for parabolic PDE systems via dissipativity analysis
This page was built for publication: Synchrony and oscillatory dynamics for a 2-d PDE-ODE model of diffusion-mediated communication between small signaling compartments
Report a bug (only for logged in users!)Click here to report a bug for this page (MaRDI item Q4983537)
