Identifiability of linear compartmental models: the effect of moving inputs, outputs, and leaks
From MaRDI portal
Publication:5039748
DOI10.1080/03081087.2020.1812497zbMATH Open1500.92032arXiv1910.13549OpenAlexW3084405648MaRDI QIDQ5039748FDOQ5039748
Authors: Seth Gerberding, Nida Obatake, Anne Shiu 
Publication date: 4 October 2022
Published in: Linear and Multilinear Algebra (Search for Journal in Brave)
Abstract: A mathematical model is identifiable if its parameters can be recovered from data. Here we investigate, for linear compartmental models, whether (local, generic) identifiability is preserved when parts of the model -- specifically, inputs, outputs, leaks, and edges -- are moved, added, or deleted. Our results are as follows. First, for certain catenary, cycle, and mammillary models, moving or deleting the leak preserves identifiability. Next, for cycle models with up to one leak, moving inputs or outputs preserves identifiability. Thus, every cycle model with up to one leak (and at least one input and at least one output) is identifiable. Next, we give conditions under which adding leaks renders a cycle model unidentifiable. Finally, for certain cycle models with no leaks, adding specific edges again preserves identifiability. Our proofs, which are algebraic and combinatorial in nature, rely on results on elementary symmetric polynomials and the theory of input-output equations for linear compartmental models.
Full work available at URL: https://arxiv.org/abs/1910.13549
Recommendations
- Linear compartmental models: input-output equations and operations that preserve identifiability
- Identifiability results for several classes of linear compartment models
- Identifiable paths and cycles in linear compartmental models
- Identifiability of linear compartmental tree models and a general formula for input-output equations
- Identifiability of linear compartmental models: the singular locus
Cites Work
- On identifiability of nonlinear ODE models and applications in viral dynamics
- Identifiable reparametrizations of linear compartment models
- Algebraic systems biology: a case study for the Wnt pathway
- Title not available (Why is that?)
- Structural identifiability of linear compartmental systems
- Controllability and Observability of Network-of-Networks via Cartesian Products
- Apolarity and canonical forms for homogeneous polynomials
- Identifiability results on some constrained compartmental systems
- Identifiability and interval identifiability of mammillary and catenary compartmental models with some known rate constants
- Title not available (Why is that?)
- Identifiability results for several classes of linear compartment models
- Linear Compartmental Models: Input-Output Equations and Operations That Preserve Identifiability
- On the Existence of Identifiable Reparametrizations for Linear Compartment Models
- Identifiability of linear compartmental models: the singular locus
Cited In (4)
- Investigations of a compartmental model for leucine kinetics using non-linear mixed effects models with ordinary and stochastic differential equations
- Identifiable paths and cycles in linear compartmental models
- Identifiability of linear compartmental models: the singular locus
- Identifiability of linear compartmental tree models and a general formula for input-output equations
Uses Software
This page was built for publication: Identifiability of linear compartmental models: the effect of moving inputs, outputs, and leaks
Report a bug (only for logged in users!)Click here to report a bug for this page (MaRDI item Q5039748)
