Identifiability of linear compartmental models: the effect of moving inputs, outputs, and leaks
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Publication:5039748
Abstract: A mathematical model is identifiable if its parameters can be recovered from data. Here we investigate, for linear compartmental models, whether (local, generic) identifiability is preserved when parts of the model -- specifically, inputs, outputs, leaks, and edges -- are moved, added, or deleted. Our results are as follows. First, for certain catenary, cycle, and mammillary models, moving or deleting the leak preserves identifiability. Next, for cycle models with up to one leak, moving inputs or outputs preserves identifiability. Thus, every cycle model with up to one leak (and at least one input and at least one output) is identifiable. Next, we give conditions under which adding leaks renders a cycle model unidentifiable. Finally, for certain cycle models with no leaks, adding specific edges again preserves identifiability. Our proofs, which are algebraic and combinatorial in nature, rely on results on elementary symmetric polynomials and the theory of input-output equations for linear compartmental models.
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Cites work
- scientific article; zbMATH DE number 4200085 (Why is no real title available?)
- scientific article; zbMATH DE number 739282 (Why is no real title available?)
- Algebraic systems biology: a case study for the Wnt pathway
- Apolarity and canonical forms for homogeneous polynomials
- Controllability and Observability of Network-of-Networks via Cartesian Products
- Identifiability and interval identifiability of mammillary and catenary compartmental models with some known rate constants
- Identifiability of linear compartmental models: the singular locus
- Identifiability results for several classes of linear compartment models
- Identifiability results on some constrained compartmental systems
- Identifiable reparametrizations of linear compartment models
- Linear compartmental models: input-output equations and operations that preserve identifiability
- On identifiability of nonlinear ODE models and applications in viral dynamics
- On the existence of identifiable reparametrizations for linear compartment models
- Structural identifiability of linear compartmental systems
Cited in
(7)- Identifiability of linear compartmental tree models and a general formula for input-output equations
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- On the existence of identifiable reparametrizations for linear compartment models
- Identifiability of linear compartmental models: the singular locus
- Linear compartmental models: input-output equations and operations that preserve identifiability
- Identifiable paths and cycles in linear compartmental models
- Investigations of a compartmental model for leucine kinetics using non-linear mixed effects models with ordinary and stochastic differential equations
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