A central limit theorem for the spatial -Fleming-Viot process with selection

DOI10.1214/16-EJP20MaRDI QIDQ508458zbMATH OpenOpenAlexFDO

Authors Raphaël Forien, Sarah Penington

Publication date 7 February 2017

Published in Electronic Journal of Probability (Search for Journal in Brave)

Full work available at URL https://arxiv.org/abs/1512.06163, https://projecteuclid.org/euclid.ejp/1484622022

zbMATH Keywords

central limit theoremFisher-KPP equationgeneralised Fleming-Viot processpopulation geneticsstochastic heat equation

Mathematics Subject Classification ID

Central limit and other weak theorems (60F05) Gaussian processes (60G15) Random measures (60G57) Stochastic partial differential equations (aspects of stochastic analysis) (60H15) Continuous-time Markov processes on general state spaces (60J25) Genetics and epigenetics (92D10) Problems related to evolution (92D15)

Abstract: We study the evolution of gene frequencies in a population living in $mathbb{R}^d$, modelled by the spatial Lambda Fleming-Viot process with natural selection (Barton, Etheridge and Veber, 2010 and Etheridge, Veber and Yu, 2014). We suppose that the population is divided into two genetic types, $a$ and $A$, and consider the proportion of the population which is of type $a$ at each spatial location. If we let both the selection intensity and the fraction of individuals replaced during reproduction events tend to zero, the process can be rescaled so as to converge to the solution to a reaction-diffusion equation (typically the Fisher-KPP equation, as in Etheridge, Veber and Yu, 2014). We show that the rescaled fluctuations converge in distribution to the solution to a linear stochastic partial differential equation. Depending on whether offspring dispersal is only local or if large scale extinction-recolonization events are allowed to take place, the limiting equation is either the stochastic heat equation with a linear drift term driven by space-time white noise or the corresponding fractional heat equation driven by a coloured noise which is white in time. If individuals are diploid (i.e. either $AA$, $Aa$ or $aa$) and if natural selection favours heterozygous ($Aa$) individuals, a stable intermediate gene frequency is maintained in the population. We give estimates for the asymptotic effect of random fluctuations around the equilibrium frequency on the local average fitness in the population. In particular, we find that the size of this effect - known as the drift load - depends crucially on the dimension $d$ of the space in which the population evolves, and is reduced relative to the case without spatial structure.

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(13)

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• The spatial Lambda-Fleming-Viot process with fluctuating selection
• Stochastic partial differential equations describing neutral genetic diversity under short range and long range dispersal
• Extinction threshold and large population limit of a plant metapopulation model with recurrent extinction events and a seed bank component
• Genealogical constructions of population models
• On \(\Lambda\)-Fleming-Viot processes with general frequency-dependent selection
• The spatial \(\Lambda\)-Fleming-Viot process in a random environment
• Measure-valued growth processes in continuous space and growth properties starting from an infinite interface
• Central limit theorems describing isolation by distance under various forms of power-law dispersal
• Central limit theorems describing isolation by distance under varying population size
• Non-equilibrium fluctuations for a spatial logistic branching process with weak competition

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