A statistical model to assess (allele-specific) associations between gene expression and epigenetic features using sequencing data

DOI10.1214/16-AOAS973MaRDI QIDQ512430zbMATHOpenAlexWikidataFDO

Authors Naim U. Rashid, Wei Sun, Joseph G. Ibrahim

Publication date 24 February 2017

Published in The Annals of Applied Statistics (Search for Journal in Brave)

Full work available at URL https://doi.org/10.1214/16-aoas973

zbMATH Keywords

geneticsRNA-seqgenomicsbivariate binomial logistic-normal (BBLN) distributionbivariate Poisson log-normal (BPLN) distributionDNase-seq

Mathematics Subject Classification ID

Applications of statistics to biology and medical sciences; meta analysis (62P10) Protein sequences, DNA sequences (92D20)

Recommendations

• Wavelet-based genetic association analysis of functional phenotypes arising from high-throughput sequencing assays
• Fully Bayesian analysis of allele-specific RNA-seq data
• Improved detection of epigenomic marks with mixed-effects hidden Markov models
• Estimating DNA methylation levels by joint modeling of multiple methylation profiles from microarray data
• Contrastive latent variable modeling with application to case-control sequencing experiments

Cited in

(3)

• Predicting methylation from sequence and gene expression using deep learning with attention
• A random coefficients model for regional co-expression associated with DNA copy number
• Wavelet-based genetic association analysis of functional phenotypes arising from high-throughput sequencing assays

This page was built for publication: A statistical model to assess (allele-specific) associations between gene expression and epigenetic features using sequencing data

Report a bug (only for logged in users!)Click here to report a bug for this page (MaRDI item Q512430)