A dynamical model of oncotripsy by mechanical cell fatigue: selective cancer cell ablation by low-intensity pulsed ultrasound

DOI10.1098/RSPA.2019.0692MaRDI QIDQ5160895zbMATH OpenOpenAlexWikidataFDO

Authors

Publication date 29 October 2021

Published in Proceedings of the Royal Society A: Mathematical, Physical and Engineering Sciences (Search for Journal in Brave)

Full work available at URL https://arxiv.org/abs/1911.12407, https://resolver.caltech.edu/CaltechAUTHORS:20191223-114059821

zbMATH Keywords

biomechanicsfatigueultrasoundlow-intensity pulsed ultrasoundoncotripsy

Mathematics Subject Classification ID

Medical applications (general) (92C50) Cell movement (chemotaxis, etc.) (92C17)

Abstract: The method of oncotripsy, first proposed in [S. Heyden and M. Ortiz (2016). Oncotripsy: Targeting cancer cells selectively via resonant harmonic excitation. Journal of the Mechanics and Physics of Solids, 92:164-175], exploits aberrations in the material properties and morphology of cancerous cells in order to ablate them selectively by means of tuned low-intensity pulsed ultrasound (LIPUS). We propose a dynamical model of oncotripsy that follows as an application of cell dynamics, statistical mechanical theory of network elasticity and 'birth-death' kinetics to describe processes of damage and repair of the cytoskeleton. We also develop a reduced dynamical model that approximates the three-dimensional dynamics of the cell and facilitates parametric studies, including sensitivity analysis and process optimization. We show that the dynamical model predicts---and provides a conceptual basis for understanding---the oncotripsy effect and other trends in the data of [D. R. Mittelstein, J. Ye, E. F. Schibber, A. Roychoudhury, L. T. Martinez, M. H. Fekrazad, M. Ortiz, P. P. Lee, M. G. Shapiro, M. Gharib (2019). Selective Ablation of Cancer Cells with Low Intensity Pulsed Ultrasound. BioRxiv] for cells in suspension, including the dependence of cell-death curves on cell and process parameters.

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Cites work

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Cited in

(2)

• A pilot study of parameter-optimized low-intensity pulsed ultrasound stimulation for the bone marrow mesenchymal stem cells viability improvement
• Model of cell membrane in ultrasonic field

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