From a discrete model of chemotaxis with volume-filling to a generalized Patlak-Keller-Segel model

DOI10.1098/RSPA.2019.0871zbMATH Open1472.92062arXiv1912.07488OpenAlexW3025246673WikidataQ96304314 ScholiaQ96304314MaRDI QIDQ5160944FDOQ5160944

Authors: Federica Bubba, T. Lorenzi, Fiona R. Macfarlane 

Publication date: 29 October 2021

Published in: Proceedings of the Royal Society A: Mathematical, Physical and Engineering Sciences (Search for Journal in Brave)

Abstract: We present a discrete model of chemotaxis whereby cells responding to a chemoattractant are seen as individual agents whose movement is described through a set of rules that result in a biased random walk. In order to take into account possible alterations in cellular motility observed at high cell densities (i.e. volume-filling), we let the probabilities of cell movement be modulated by a decaying function of the cell density. We formally show that a general form of the celebrated Patlak-Keller-Segel (PKS) model of chemotaxis can be formally derived as the appropriate continuum limit of this discrete model. The family of steady-state solutions of such a generalised PKS model are characterised and the conditions for the emergence of spatial patterns are studied via linear stability analysis. Moreover, we carry out a systematic quantitative comparison between numerical simulations of the discrete model and numerical solutions of the corresponding PKS model, both in one and in two spatial dimensions. The results obtained indicate that there is excellent quantitative agreement between the spatial patterns produced by the two models. Finally, we numerically show that the outcomes of the two models faithfully replicate those of the classical PKS model in a suitable asymptotic regime.

Full work available at URL: https://arxiv.org/abs/1912.07488

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zbMATH Keywords

chemotaxisdiscrete modelsmathematical modellingapplied mathematicsvolume-fillinggeneralized Patlak-Keller-Segel model

Mathematics Subject Classification ID

Cell movement (chemotaxis, etc.) (92C17)

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Cited In (10)

• Treatment-induced shrinking of tumour aggregates: a nonlinear volume-filling chemotactic approach
• A hybrid model of collective motion of discrete particles under alignment and continuum chemotaxis
• Patterns in a generalized volume-filling chemotaxis model with cell proliferation
• Hydrodynamic limit of a stochastic model of proliferating cells with chemotaxis
• A one-dimensional model for the interaction between cell-to-cell adhesion and chemotactic signalling
• Agent-based and continuum models for spatial dynamics of infection by oncolytic viruses
• Predicting population extinction in lattice-based birth–death–movement models
• A hybrid discrete-continuum approach to model Turing pattern formation
• A hybrid discrete-continuum modelling approach to explore the impact of T-cell infiltration on anti-tumour immune response
• The impact of phenotypic heterogeneity on chemotactic self-organisation

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