Permanent Charge Effects on Ionic Flow: A Numerical Study of Flux Ratios and Their Bifurcation
From MaRDI portal
Publication:5163907
Abstract: Ionic flow carries electrical signals for cells to communicate with each other. The permanent charge of an ion channel is a crucial protein structure for flow properties while boundary conditions play a role of the driving force. Their effects on flow properties have been analyzed via a quasi-one-dimensional Poisson-Nernst-Planck model for small and relatively large permanent charges. The analytical studies have led to the introduction of flux ratios that reflect permanent charge effects and have a universal property. The studies also show that the flux ratios have different behaviors for small and large permanent charges. However, the existing analytical techniques can reveal neither behaviors of flux ratios nor transitions between small and large permanent charges. In this work we present a numerical investigation on flux ratios to bridge between small and large permanent charges. Numerical results verify the analytical predictions for the two extremal regions. More significantly, emergence of non-trivial behaviors is detected as the permanent charge varies from small to large. In particular, saddle-node bifurcations of flux ratios are revealed, showing rich phenomena of permanent charge effects by the power of combining analytical and numerical techniques. An adaptive moving mesh finite element method is used in the numerical studies.
Recommendations
- Effects of large permanent charges on ionic flows via Poisson-Nernst-Planck models
- Effects of (small) permanent charge and channel geometry on ionic flows via classical Poisson-Nernst-Planck models
- Reversal permanent charge and concentrations in ionic flows via Poisson-Nernst-Planck models
- Small permanent charge effects on individual fluxes via Poisson-Nernst-Planck models with multiple cations
- Finite ion size effects on ionic flows via Poisson-Nernst-Planck systems: higher order contributions
- Boundary layer effects on ionic flows via Poisson-Nernst-Planck systems with nonuniform ion sizes
- Boundary layer effects on ionic flows via classical Poisson-Nernst-Planck systems
- Multiscale analysis of ionic transport in periodic charged media
- A numerical approach to ionic transport through charged membranes
- Ion size and valence effects on ionic flows via Poisson-Nernst-Planck models
Cites work
- A flux ratio and a universal property of permanent charges effects on fluxes
- A local approximation of fundamental measure theory incorporated into three dimensional Poisson-Nernst-Planck equations to account for hard sphere repulsion among ions
- A mathematical model for the hard sphere repulsion in ionic solutions
- Adaptive moving mesh methods
- Adaptivity with moving grids
- An energetic variational approach to ion channel dynamics
- Effects of (small) permanent charge and channel geometry on ionic flows via classical Poisson-Nernst-Planck models
- Effects of large permanent charges on ionic flows via Poisson-Nernst-Planck models
- Energy variational approach to study charge inversion (layering) near charged walls
- Flux ratios and channel structures
- scientific article; zbMATH DE number 702824 (Why is no real title available?)
- scientific article; zbMATH DE number 5049170 (Why is no real title available?)
- Ion Flow through Narrow Membrane Channels: Part I
- Mathematical study of non-ideal electrostatic correlations in equilibrium electrolytes
- Non-localness of excess potentials and boundary value problems of Poisson-Nernst-Planck systems for ionic flow: a case study
- On the mesh nonsingularity of the moving mesh PDE method
- One-dimensional steady-state Poisson-Nernst-Planck systems for ion channels with multiple ion species
- Poisson-Nernst-Planck systems for ion flow with density functional theory for hard-sphere potential: I-V relations and critical potentials. I: Analysis
- Poisson-Nernst-Planck systems for ion flow with density functional theory for hard-sphere potential: I-V relations and critical potentials. II: Numerics
- Poisson-Nernst-Planck systems for narrow tubular-like membrane channels
- Poisson–Nernst–Planck Systems for Ion Channels with Permanent Charges
- Reversal permanent charge and reversal potential: case studies via classical Poisson-Nernst-Planck models
- Variational multiscale models for charge transport
- Velocity-based moving mesh methods for nonlinear partial differential equations
Cited in
(10)- A flux ratio and a universal property of permanent charges effects on fluxes
- Ионные потоки заряженных частиц в катодной области тлеющего разряда
- Dynamics of Poisson-Nernst-Planck Systems and Ionic Flows Through Ion Channels: A Review
- Effects of ion sizes on Poisson–Nernst–Planck systems with multiple ions
- Flux ratios for effects of permanent charges on ionic flows with three ion species: new phenomena from a case study
- Poisson-Nernst-Planck models for three ion species: monotonic profiles vs. oscillatory profiles
- Flux ratios for effects of permanent charges on ionic flows with three ion species: case study. II
- Flux ratios for effects of permanent charges on ionic flows with three ion species: a universality. III
- Exploring multiple timescale dynamics using geometric singular perturbation-informed neural networks (GSPINNs)
- Finite ion size and permanent charge in a Poisson-Nernst-Planck ion channel model: existence and a critical potential phenomenon
This page was built for publication: Permanent Charge Effects on Ionic Flow: A Numerical Study of Flux Ratios and Their Bifurcation
Report a bug (only for logged in users!)Click here to report a bug for this page (MaRDI item Q5163907)
