One-dimensional steady-state Poisson-Nernst-Planck systems for ion channels with multiple ion species

DOI10.1016/J.JDE.2008.09.010MaRDI QIDQ2378201zbMATH OpenOpenAlexFDO

Authors Weishi Liu

Publication date 7 January 2009

Published in Journal of Differential Equations (Search for Journal in Brave)

Full work available at URL https://doi.org/10.1016/j.jde.2008.09.010

zbMATH Keywords

Geometric singular perturbationmultiple steady-statesspatial oscillations

Mathematics Subject Classification ID

Geometric methods in ordinary differential equations (34A26) Nonlinear boundary value problems for ordinary differential equations (34B15) Singular perturbations for ordinary differential equations (34E15) Singular perturbations, turning point theory, WKB methods for ordinary differential equations (34E20) Physiological flow (92C35)

Review text

The one-dimensional Poisson-Nernst-Planck (PNP) system is a basic model for ion flow through membrane channels. If the Debye length is much smaller than the characteristic radius of the channel, the PNP system can be treated as a singularly perturbed system. The paper provides a geometric framework for the study of the steady-state PNP system involving multiple types of ion species with multiple regions of piecewise constant permanent charge. The article starts with a description of a three-dimensional PNP system as the model for ion flows through an ion channel and discusses a one-dimensional reduction. Special structures of this particular problem are revealed, which together with the general framework allow one to reduce the existence and multiplicity of singular orbits to a system of nonlinear algebraic equations. Near each singular orbit, an application of the exchange lemma from the geometric singular perturbation theory gives rise to the existence and (local) uniqueness of a solution of the singular boundary value problem. A new phenomenon on multiplicity and spatial behavior of steady-state involving three or more types of ion species is discovered in an example.

Recommendations

• Geometric Singular Perturbation Approach to Steady-State Poisson--Nernst--Planck Systems
• Poisson–Nernst–Planck Systems for Ion Channels with Permanent Charges
• Dynamics of classical Poisson-Nernst-Planck systems with multiple cations and boundary layers
• Existence and local uniqueness of classical Poisson-Nernst-Planck systems with multi-component permanent charges and multiple cations
• Singular perturbation analysis of the steady-state Poisson–Nernst–Planck system: Applications to ion channels

Cites work

• A Bifurcation Analysis of the One-Dimensional Steady-State Semiconductor Device Equations
• A Finite Element Approximation Theory for the Drift Diffusion Semiconductor Model
• A Poisson-Nernst-Planck model for biological ion channels -- an asymptotic analysis in a three-dimensional narrow funnel
• Asymptotic Analysis of the Current-Voltage Curve of a pnpn Semiconductor Device
• Asymptotic Expansions of I-V Relations via a Poisson–Nernst–Planck System
• Diffusion Limit of a Semiconductor Boltzmann–Poisson System
• Exchange lemmas for singular perturbation problems with certain turning points
• Geometric Singular Perturbation Approach to Steady-State Poisson--Nernst--Planck Systems
• Geometric singular perturbation theory for ordinary differential equations
• scientific article; zbMATH DE number 799793 (Why is no real title available?)
• scientific article; zbMATH DE number 824828 (Why is no real title available?)
• Identification of doping profiles in semiconductor devices
• Invariant manifolds
• Invariant Manifolds and Singularly Perturbed Boundary Value Problems
• Inverse Problems Related to Ion Channel Selectivity
• Ion Flow through Narrow Membrane Channels: Part I
• Ion Flow through Narrow Membrane Channels: Part II
• Nonlinear Ionic Diffusion Through Charged Polymeric Gels
• On inverse problems for semiconductor equations
• Ordinary differential equations with applications
• Poisson-Nernst-Planck systems for narrow tubular-like membrane channels
• Poisson–Nernst–Planck Systems for Ion Channels with Permanent Charges
• Qualitative Properties of Steady-State Poisson--Nernst--Planck Systems: Mathematical Study
• Qualitative Properties of Steady-State Poisson--Nernst--Planck Systems: Perturbation and Simulation Study
• Singular perturbation analysis of the steady-state Poisson–Nernst–Planck system: Applications to ion channels
• Tracking Invariant Manifolds up to Exponentially Small Errors
• Tracking invariant manifolds with differential forms in singularly perturbed systems
• Two- and three-dimensional Poisson--Nernst--Planck simulations of current flow through gramicidin A

Cited in

(84)

• The existence of solitary wave solutions of delayed Camassa-Holm equation via a geometric approach
• Non-localness of excess potentials and boundary value problems of Poisson-Nernst-Planck systems for ionic flow: a case study
• Geometric singular approach to Poisson-Nernst-Planck models with excess chemical potentials: ion size effects on individual fluxes
• Relative dielectric constants and selectivity ratios in open ionic channels
• Ion size effects on individual fluxes via Poisson-Nernst-Planck systems with Bikerman's local hard-sphere potential: analysis without electroneutrality boundary conditions
• Poisson-Nernst-Planck equations with steric effects -- non-convexity and multiple stationary solutions
• The mathematics of mechanobiology and cell signaling. Abstracts from the workshop held February 25--March 3, 2018
• Two-dimensional equations for thin-films of ionic conductors
• Boundary layer effects on ionic flows via classical Poisson-Nernst-Planck systems
• A flux ratio and a universal property of permanent charges effects on fluxes
• Poisson-Nernst-Planck systems for ion flow with density functional theory for hard-sphere potential: I-V relations and critical potentials. I: Analysis
• Poisson-Nernst-Planck systems for ion flow with density functional theory for hard-sphere potential: I-V relations and critical potentials. II: Numerics
• Global existence of large solutions for the generalized Poisson-Nernst-Planck equations
• Small permanent charge effects on individual fluxes via Poisson-Nernst-Planck models with multiple cations
• Parabolic-elliptic system modeling biological ion channels
• Dynamics of ionic flows via Poisson-Nernst-Planck systems with local hard-sphere potentials: competition between cations
• Traveling wave fronts in a diffusive and competitive Lotka-Volterra system
• Solitary wave solutions of delayed coupled Higgs field equation
• Geometric singular perturbation approach to Poisson-Nernst-Planck systems with local hard-sphere potential: studies on zero-current ionic flows with boundary layers
• Studies on reversal permanent charges and reversal potentials via classical Poisson-Nernst-Planck systems with boundary layers
• Qualitative properties of zero-current ionic flows via Poisson-Nernst-Planck systems with nonuniform ion sizes
• Boundary layer effects on ionic flows via Poisson-Nernst-Planck systems with nonuniform ion sizes
• Superconvergent estimate of a Galerkin finite element method for nonlinear Poisson-Nernst-Planck equations
• Fast-slow dynamics for intraguild predation models with evolutionary effects
• Dynamics of classical Poisson-Nernst-Planck systems with multiple cations and boundary layers
• A complete analysis of a classical Poisson-Nernst-Planck model for ionic flow
• Electric potential generation of electrocytes: modelling, analysis, and computation
• Mathematical studies of Poisson-Nernst-Planck model for membrane channels: finite ion size effects without electroneutrality boundary conditions
• Flux ratios and channel structures
• Largest well-posed spaces for the general diffusion system with nonlocal interactions
• Numerical algorithms based on Galerkin methods for the modeling of reactive interfaces in photoelectrochemical (PEC) solar cells
• Asymptotic analysis of charge conserving Poisson-Boltzmann equations with variable dielectric coefficients
• Time-dependent Langevin modeling and Monte Carlo simulations of diffusion in one-dimensional ion channels
• A Poisson-Nernst-Planck single ion channel model and its effective finite element solver
• Multiple solutions of steady-state Poisson-Nernst-Planck equations with steric effects
• Individual flux study via steady-state Poisson-Nernst-Planck systems: effects from boundary conditions
• A note on the classical Poisson-Nernst-Planck models
• Qualitative properties of ionic flows via Poisson-Nernst-Planck systems with Bikerman's local hard-sphere potential: ion size effects
• Geometric singular perturbation method to the existence and asymptotic behavior of traveling waves for a generalized Burgers-KdV equation
• On the modeling and simulation of reaction-transfer dynamics in semiconductor-electrolyte solar cells
• Singular perturbation analysis of the steady-state Poisson–Nernst–Planck system: Applications to ion channels
• A Poisson-Nernst-Planck model for biological ion channels -- an asymptotic analysis in a three-dimensional narrow funnel
• Qualitative Properties of Steady-State Poisson--Nernst--Planck Systems: Mathematical Study
• Qualitative Properties of Steady-State Poisson--Nernst--Planck Systems: Perturbation and Simulation Study
• Solutions to a nonlinear Poisson-Nernst-Planck system in an ionic channel
• Effects of large permanent charges on ionic flows via Poisson-Nernst-Planck models
• Mathematical analysis of Poisson-Nernst-Planck models with permanent charges and boundary layers: studies on individual fluxes
• Effects on \(I-V\) relations from small permanent charge and channel geometry via classical Poisson-Nernst-Planck equations with multiple cations
• Existence of solutions to the Poisson-Nernst-Planck system with singular permanent charges in \(\mathbb{R}^2\)
• Reversal potential and reversal permanent charge with unequal diffusion coefficients via classical Poisson-Nernst-Planck models
• Gevrey regularity and time decay of the fractional Debye-Hückel system in Fourier-Besov spaces
• Reversal permanent charge and concentrations in ionic flows via Poisson-Nernst-Planck models
• Computational study on hysteresis of ion channels: multiple solutions to steady-state Poisson-Nernst-Planck equations
• Permanent Charge Effects on Ionic Flow: A Numerical Study of Flux Ratios and Their Bifurcation
• Geometric Singular Perturbation Approach to Steady-State Poisson--Nernst--Planck Systems
• Poisson–Nernst–Planck Systems for Ion Channels with Permanent Charges
• Error analysis of finite element method for Poisson-Nernst-Planck equations
• A Maxwell–Ampère Nernst–Planck Framework for Modeling Charge Dynamics
• Poisson-Nernst-Planck systems for narrow tubular-like membrane channels
• Nonconforming finite element method for coupled <scp>Poisson–Nernst–Planck</scp> equations
• Existence and local uniqueness of classical Poisson-Nernst-Planck systems with multi-component permanent charges and multiple cations
• Dynamics of Poisson-Nernst-Planck Systems and Ionic Flows Through Ion Channels: A Review
• Renormalization group method for solving initial value problem of slow‐fast system
• Effects of ion sizes on Poisson–Nernst–Planck systems with multiple ions
• Finite ion size effects on ionic flows via Poisson-Nernst-Planck systems: higher order contributions
• Flux ratios for effects of permanent charges on ionic flows with three ion species: new phenomena from a case study
• Studies on individual fluxes via Poisson-Nernst-Planck models with small permanent charges and partial electroneutrality conditions
• Higher order expansions in finite ion size via Poisson-Nernst-Planck systems with Bikerman's local hard-sphere potential
• Studies on current-voltage relations via Poisson-Nernst-Planck systems with multiple cations and permanent charges
• Poisson-Nernst-Planck models for three ion species: monotonic profiles vs. oscillatory profiles
• Flux ratios for effects of permanent charges on ionic flows with three ion species: case study. II
• Flux ratios for effects of permanent charges on ionic flows with three ion species: a universality. III
• Studies on reversal potential via classical Poisson-Nernst-Planck systems. I: Multiple pieces of nonzero permanent charges having the same sign
• Dynamical properties of singularly perturbed renormalization group approach to slow-fast systems
• Ionic flux calculation by an extended Goldman-Hodgkin-Katz equation accounting for nonlinear ion channel electrostatics
• Nonlinear conformation response in the finite channel: existence of a unique solution for the dynamic PNP model
• Exploring multiple timescale dynamics using geometric singular perturbation-informed neural networks (GSPINNs)
• Multiple solutions in the steady Poisson-Nernst-Planck models of electrodiffusion
• Structure-preserving discretization of the Poisson-Nernst-Planck equations via the Onsager principle
• Gevrey regularity of mild solutions to the parabolic-elliptic system of drift-diffusion type in critical Besov spaces
• The influence of small permanent charges and partial boundary conditions on individual fluxes via Poisson-Nernst-Planck systems
• Finite ion size and permanent charge in a Poisson-Nernst-Planck ion channel model: existence and a critical potential phenomenon
• Electric discharge of electrocytes: modelling, analysis and simulation
• Asymptotic expansions and numerical simulations of I-V relations via a steady state Poisson-Nernst-Planck system

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