Relative dielectric constants and selectivity ratios in open ionic channels
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Abstract: We investigate the effects of the relative dielectric coefficient on ionic flows in open ion channels, using mathematical analysis of reasonably general Poisson-Nernst-Planck type models that can include the finite sizes of ions. The value of the relative dielectric coefficient is of course a crucial parameter for ionic behavior in general. Using the powerful theory of singularly perturbed problems in applied mathematics, we show that some properties of open channels are quite insensitive to variation in the relative dielectric coefficient, thereby explaining such effects seen unexpectedly in simulations. The ratio between the total number of one ion species and that of another ion species, and the ratio between the flux of one ion species and that of another ion species do not depend significantly on the relative dielectric coefficient.
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Cited in
(9)- Small permanent charge effects on individual fluxes via Poisson-Nernst-Planck models with multiple cations
- Reversal permanent charge and concentrations in ionic flows via Poisson-Nernst-Planck models
- A flux ratio and a universal property of permanent charges effects on fluxes
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- Qualitative properties of zero-current ionic flows via Poisson-Nernst-Planck systems with nonuniform ion sizes
- Dynamics of Poisson-Nernst-Planck Systems and Ionic Flows Through Ion Channels: A Review
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