Accurate reduction of a model of circadian rhythms by delayed quasi steady state assumptions

DOI10.21136/MB.2014.144135MaRDI QIDQ5249608zbMATH OpenOpenAlexFDO

Authors Tomas Vejchodsky

Publication date 6 May 2015

Full work available at URL https://arxiv.org/abs/1312.2825, http://hdl.handle.net/10338.dmlcz/144135

zbMATH Keywords

accurate approximationbiochemical networksdelay differential equationsgene regulatory networksmodel reductionoscillating systemsperiodic solutions

Mathematics Subject Classification ID

Nonlinear oscillations and coupled oscillators for ordinary differential equations (34C15) Biological rhythms and synchronization (92B25) Biochemistry, molecular biology (92C40)

Abstract: Quasi steady state assumptions are often used to simplify complex systems of ordinary differential equations in modelling of biochemical processes. The simplified system is designed to have the same qualitative properties as the original system and to have a small number of variables. This enables to use the stability and bifurcation analysis to reveal a deeper structure in the dynamics of the original system. This contribution shows that introducing delays to quasi steady state assumptions yields a simplified system that accurately agrees with the original system not only qualitatively but also quantitatively. We derive the proper size of the delays for a particular model of circadian rhythms and present numerical results showing the accuracy of this approach.

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Cited in

(5)

• Reducing the complexity of mathematical models for the plant circadian clock by distributed delays
• Effective reduction of a three-dimensional circadian oscillator model
• On an optimal setting of constant delays for the D-QSSA model reduction method applied to a class of chemical reaction networks.
• Methods of model reduction for large-scale biological systems: a survey of current methods and trends
• Galerkin-least squares approximations for delay differential equations: application to a circadian rhythm model

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