On an optimal setting of constant delays for the D-QSSA model reduction method applied to a class of chemical reaction networks.

DOI10.21136/AM.2022.0136-21MaRDI QIDQ2093348zbMATH OpenOpenAlexFDO

Authors Ctirad Matonoha, Štěpán Papáček, V. Lynnyk

Publication date 7 November 2022

Published in Applications of Mathematics (Search for Journal in Brave)

Full work available at URL https://doi.org/10.21136/am.2022.0136-21

zbMATH Keywords

D-QSSA methodmodel reductionoptimizationquasi-steady-state approximationreaction networksingular perturbation

Mathematics Subject Classification ID

Nonlinear ordinary differential equations and systems (34A34) Numerical optimization and variational techniques (65K10) Kinetics in biochemical problems (pharmacokinetics, enzyme kinetics, etc.) (92C45)

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Cites work

• A comparison of two FEM-based methods for the solution of the nonlinear output regulation problem
• Accurate reduction of a model of circadian rhythms by delayed quasi steady state assumptions
• An Introduction to Delay Differential Equations with Applications to the Life Sciences
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• scientific article; zbMATH DE number 1893717 (Why is no real title available?)
• Input-output systems in Biology and Chemistry and a class of mathematical models describing them.
• Methods of model reduction for large-scale biological systems: a survey of current methods and trends
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• Observer design for a time delay system via the Razumikhin approach
• On a class of stochastic models of cell biology: periodicity and controllability
• On parameter estimation in an in vitro compartmental model for drug-induced enzyme production in pharmacotherapy.
• On the validity of the steady state assumption of enzyme kinetics
• The quasi-steady-state approximations revisited: timescales, small parameters, singularities, and normal forms in enzyme kinetics
• The Quasi-Steady-State Assumption: A Case Study in Perturbation

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