Effective reduction of a three-dimensional circadian oscillator model

DOI10.3934/DCDSB.2020349zbMATH Open1480.34059arXiv1910.12421OpenAlexW3041530519MaRDI QIDQ2033859FDOQ2033859

Jinqiao Duan, Shuang Chen, Ji Li

Publication date: 18 June 2021

Published in: Discrete and Continuous Dynamical Systems. Series B (Search for Journal in Brave)

Abstract: We investigate the dynamics of a three-dimensional system modeling a molecular mechanism for the circadian rhythm in Drosophila. We first prove the existence of a compact attractor in the region with biological meaning. Under the assumption that the dimerization reactions are fast, in this attractor we reduce the three-dimensional system to a simpler two-dimensional system on the persistent normally hyperbolic slow manifold.

Full work available at URL: https://arxiv.org/abs/1910.12421

Recommendations

• Dynamics of the Tyson-Hong-Thron-Novak circadian oscillator model
• Accurate reduction of a model of circadian rhythms by delayed quasi steady state assumptions
• Dimension reduction for stochastic dynamical systems forced onto a manifold by large drift: a constructive approach with examples from theoretical biology
• Model Reduction and Physical Understanding of Slowly Oscillating Processes: The Circadian Cycle
• Reconciling mathematical models of biological clocks by averaging on approximate manifolds

zbMATH Keywords

geometric singular perturbation theoryreduced modelslow manifoldcircadian oscillatorFenichel's theorem

Mathematics Subject Classification ID

Qualitative investigation and simulation of ordinary differential equation models (34C60) Transformation and reduction of ordinary differential equations and systems, normal forms (34C20) Invariant manifolds for ordinary differential equations (34C45) Singular perturbations for ordinary differential equations (34E15) Cell biology (92C37)

Cites Work

• Title not available (Why is that?)
• The Sil'nikov problem, exponential expansion, strong \(\lambda\)-lemma, \(C^ 1\)-linearization, and homoclinic bifurcation
• Geometric singular perturbation theory for ordinary differential equations
• Mathematical physiology
• Geometric singular perturbation theory in biological practice
• Qualitative theory of planar differential systems
• Geometric analysis of the Goldbeter minimal model for the embryonic cell cycle
• Extending geometric singular perturbation theory to nonhyperbolic points -- fold and canard points in two dimensions
• Multiple time scale dynamics
• Title not available (Why is that?)
• Title not available (Why is that?)
• Canard cycles and center manifolds
• Title not available (Why is that?)
• Asymptotic analysis of two reduction methods for systems of chemical reactions
• Title not available (Why is that?)
• Title not available (Why is that?)
• Title not available (Why is that?)
• Relaxation oscillation and canard explosion
• Canard cycles for predator-prey systems with Holling types of functional response
• Normally hyperbolic invariant manifolds in dynamical systems
• Exchange lemmas for singular perturbation problems with certain turning points
• Tracking Invariant Manifolds up to Exponentially Small Errors
• Exchange lemmas 1: Deng's Lemma
• Exchange lemmas 2: General exchange Lemma
• Effects of quasi-steady-state reduction on biophysical models with oscillations
• Determining ``small parameters for quasi-steady state
• Model Reduction and Physical Understanding of Slowly Oscillating Processes: The Circadian Cycle
• Food chain chaos due to transcritical point
• The existence of solitary wave solutions of delayed Camassa-Holm equation via a geometric approach

Cited In (5)

• Periodic traveling waves with large speed
• Model Reduction and Physical Understanding of Slowly Oscillating Processes: The Circadian Cycle
• Relaxation oscillations in slow–fast IS–LM economic models
• Accurate reduction of a model of circadian rhythms by delayed quasi steady state assumptions
• Dynamics of the Tyson-Hong-Thron-Novak circadian oscillator model

This page was built for publication: Effective reduction of a three-dimensional circadian oscillator model

Report a bug (only for logged in users!)Click here to report a bug for this page (MaRDI item Q2033859)