Effective reduction of a three-dimensional circadian oscillator model
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Publication:2033859
geometric singular perturbation theoryreduced modelslow manifoldcircadian oscillatorFenichel's theorem
Qualitative investigation and simulation of ordinary differential equation models (34C60) Transformation and reduction of ordinary differential equations and systems, normal forms (34C20) Invariant manifolds for ordinary differential equations (34C45) Singular perturbations for ordinary differential equations (34E15) Cell biology (92C37)
Abstract: We investigate the dynamics of a three-dimensional system modeling a molecular mechanism for the circadian rhythm in Drosophila. We first prove the existence of a compact attractor in the region with biological meaning. Under the assumption that the dimerization reactions are fast, in this attractor we reduce the three-dimensional system to a simpler two-dimensional system on the persistent normally hyperbolic slow manifold.
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- Accurate reduction of a model of circadian rhythms by delayed quasi steady state assumptions
- Dynamics of the Tyson-Hong-Thron-Novak circadian oscillator model
- Model Reduction and Physical Understanding of Slowly Oscillating Processes: The Circadian Cycle
- Relaxation oscillations in slow–fast IS–LM economic models
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