Effective reduction of a three-dimensional circadian oscillator model

DOI10.3934/DCDSB.2020349MaRDI QIDQ2033859zbMATH OpenOpenAlexFDO

Authors Shuang Chen, Ji Li, Jinqiao Duan

Publication date 18 June 2021

Published in Discrete and Continuous Dynamical Systems. Series B (Search for Journal in Brave)

Full work available at URL https://arxiv.org/abs/1910.12421

zbMATH Keywords

circadian oscillatorFenichel's theoremgeometric singular perturbation theoryreduced modelslow manifold

Mathematics Subject Classification ID

Transformation and reduction of ordinary differential equations and systems, normal forms (34C20) Invariant manifolds for ordinary differential equations (34C45) Qualitative investigation and simulation of ordinary differential equation models (34C60) Singular perturbations for ordinary differential equations (34E15) Cell biology (92C37)

Abstract: We investigate the dynamics of a three-dimensional system modeling a molecular mechanism for the circadian rhythm in Drosophila. We first prove the existence of a compact attractor in the region with biological meaning. Under the assumption that the dimerization reactions are fast, in this attractor we reduce the three-dimensional system to a simpler two-dimensional system on the persistent normally hyperbolic slow manifold.

Review text

The authors consider a three-dimensional circardian oscillator model. Under some assumptions on the reaction rates, the model represents a singularly perturbed autonomous differential system having an invariant manifold (slow manifold) such that the original system can be reduced to a two-dimensional system.

Recommendations

• Dynamics of the Tyson-Hong-Thron-Novak circadian oscillator model
• Accurate reduction of a model of circadian rhythms by delayed quasi steady state assumptions
• Dimension reduction for stochastic dynamical systems forced onto a manifold by large drift: a constructive approach with examples from theoretical biology
• Model Reduction and Physical Understanding of Slowly Oscillating Processes: The Circadian Cycle
• Reconciling mathematical models of biological clocks by averaging on approximate manifolds

Cites work

• Asymptotic analysis of two reduction methods for systems of chemical reactions
• Canard cycles and center manifolds
• Canard cycles for predator-prey systems with Holling types of functional response
• Determining ``small parameters for quasi-steady state
• Effects of quasi-steady-state reduction on biophysical models with oscillations
• Exchange lemmas 1: Deng's Lemma
• Exchange lemmas 2: General exchange Lemma
• Exchange lemmas for singular perturbation problems with certain turning points
• Extending geometric singular perturbation theory to nonhyperbolic points -- fold and canard points in two dimensions
• Food chain chaos due to transcritical point
• Geometric analysis of the Goldbeter minimal model for the embryonic cell cycle
• Geometric singular perturbation theory for ordinary differential equations
• Geometric singular perturbation theory in biological practice
• scientific article; zbMATH DE number 3766528 (Why is no real title available?)
• scientific article; zbMATH DE number 54081 (Why is no real title available?)
• scientific article; zbMATH DE number 3569457 (Why is no real title available?)
• scientific article; zbMATH DE number 1787314 (Why is no real title available?)
• scientific article; zbMATH DE number 3446103 (Why is no real title available?)
• scientific article; zbMATH DE number 799793 (Why is no real title available?)
• scientific article; zbMATH DE number 3390024 (Why is no real title available?)
• Mathematical physiology
• Model Reduction and Physical Understanding of Slowly Oscillating Processes: The Circadian Cycle
• Multiple time scale dynamics
• Normally hyperbolic invariant manifolds in dynamical systems
• Qualitative theory of planar differential systems
• Relaxation oscillation and canard explosion
• The existence of solitary wave solutions of delayed Camassa-Holm equation via a geometric approach
• The Sil'nikov problem, exponential expansion, strong \(\lambda\)-lemma, \(C^ 1\)-linearization, and homoclinic bifurcation
• Tracking Invariant Manifolds up to Exponentially Small Errors

Cited in

(5)

• Dynamics of the Tyson-Hong-Thron-Novak circadian oscillator model
• Accurate reduction of a model of circadian rhythms by delayed quasi steady state assumptions
• Model Reduction and Physical Understanding of Slowly Oscillating Processes: The Circadian Cycle
• Periodic traveling waves with large speed
• Relaxation oscillations in slow–fast IS–LM economic models

This page was built for publication: Effective reduction of a three-dimensional circadian oscillator model

Report a bug (only for logged in users!)Click here to report a bug for this page (MaRDI item Q2033859)