Geometric analysis of the Goldbeter minimal model for the embryonic cell cycle
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blow-up techniquecell cycleenzyme kineticsgeometric singular perturbation theorymitotic oscillatorrelaxation oscillation
Qualitative investigation and simulation of ordinary differential equation models (34C60) Transformation and reduction of ordinary differential equations and systems, normal forms (34C20) Invariant manifolds for ordinary differential equations (34C45) Singular perturbations for ordinary differential equations (34E15) Cell biology (92C37) Kinetics in biochemical problems (pharmacokinetics, enzyme kinetics, etc.) (92C45) Relaxation oscillations for ordinary differential equations (34C26) Multiple scale methods for ordinary differential equations (34E13)
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Cites work
- scientific article; zbMATH DE number 799793 (Why is no real title available?)
- scientific article; zbMATH DE number 819507 (Why is no real title available?)
- Asymptotic methods for relaxation oscillations and applications
- Atomic and molecular calculations using quasirandom numbers
- Canard cycles and center manifolds
- Differential equations with small parameters and relaxation oscillations. Translation from the Russian by F. M. C. Goodspeed
- Exchange of Stabilities in Autonomous Systems
- Extending geometric singular perturbation theory to nonhyperbolic points -- fold and canard points in two dimensions
- Extending slow manifolds near transcritical and pitchfork singularities
- Geometric desingularization of a cusp singularity in slow-fast systems with applications to Zeeman's examples
- Geometric singular perturbation analysis of an autocatalator model
- Geometric singular perturbation theory for ordinary differential equations
- Geometric singular perturbation theory in biological practice
- Mathematical physiology
- Models of cellular regulation.
- Ordinary differential equations with applications
- Relaxation oscillations in \({\mathbb R}^3\)
- Rescue of the Quasi‐Steady‐State Approximation in a Model for Oscillations in an Enzymatic Cascade
- Scaling in singular perturbation problems: blowing up a relaxation oscillator
- The cell cycle is a limit cycle
- Transversal heteroclinic and homoclinic orbits in singular perturbation problems
Cited in
(29)- A geometric analysis of the SIRS epidemiological model on a homogeneous network
- A survey on the blow-up method for fast-slow systems
- Geometric analysis of oscillations in the Frzilator model
- Singularly perturbed oscillators with exponential nonlinearities
- Dynamical behavior in the modeling of cell division cycle
- Wavetrain solutions of a reaction-diffusion-advection model of mussel-algae interaction
- Singularly perturbed boundary-focus bifurcations
- Spike-adding in a canonical three-time-scale model: superslow explosion and folded-saddle canards
- Relaxation oscillations in substrate-depletion oscillators close to the nonsmooth limit
- Mathematical models of the early embryonic cell cycle: The role of MPF activation and cyclin degradation
- Model for the epigenetic mechanism during embryogenesis: a study of oscillations in a multiple-loop biochemical control network
- Process-oriented geometric singular perturbation theory and calcium dynamics
- The regularized visible fold revisited
- Scaling in singular perturbation problems: blowing up a relaxation oscillator
- Asymptotic analysis of a target-mediated drug disposition model: algorithmic and traditional approaches
- A geometric analysis of the SIR, SIRS and SIRWS epidemiological models
- Effective reduction of a three-dimensional circadian oscillator model
- Geometric blow-up for folded limit cycle manifolds in three time-scale systems
- Discrete geometric singular perturbation theory
- Parameter-robustness analysis for a biochemical oscillator model describing the social-behaviour transition phase of myxobacteria
- Slow unfoldings of contact singularities in singularly perturbed systems beyond the standard form
- Geometric singular perturbation analysis of a dynamical target mediated drug disposition model
- A stiction oscillator with canards: on piecewise smooth nonuniqueness and its resolution by regularization using geometric singular perturbation theory
- Understanding broad-spike oscillations in a model of intracellular calcium dynamics
- A stiction oscillator under slowly varying forcing: uncovering small scale phenomena using blowup
- A new type of relaxation oscillation in a model with rate-and-state friction
- Two-stroke relaxation oscillators
- Revisiting the Kepler problem with linear drag using the blowup method and normal form theory
- The number of limit cycles for regularized piecewise polynomial systems is unbounded
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