Testing interaction between treatment and high‐dimensional covariates in randomized clinical trials

DOI10.1002/BIMJ.201500194MaRDI QIDQ5280183zbMATH OpenOpenAlexWikidataFDO

Authors Andrea Callegaro, Bart Spiessens, Benjamin Dizier, Fernando U. Montoya, Hans van Houwelingen

Publication date 20 July 2017

Published in Biometrical Journal (Search for Journal in Brave)

Full work available at URL https://doi.org/10.1002/bimj.201500194

zbMATH Keywords

high-dimensional dataclinical trialglobal testinteractionpredictive biomarker

Mathematics Subject Classification ID

Reliability and life testing (62N05) Applications of statistics to biology and medical sciences; meta analysis (62P10)

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Cites work

• A predictive enrichment procedure to identify potential responders to a new therapy for randomized, comparative controlled clinical studies
• A simple method for estimating interactions between a treatment and a large number of covariates
• Dynamic prediction in clinical survival analysis
• Estimating individualized treatment rules using outcome weighted learning

Cited in

(7)

• A simple method for estimating interactions between a treatment and a large number of covariates
• LRBmat: a novel gut microbial interaction and individual heterogeneity inference method for colorectal cancer
• Discovering interactions using covariate informed random partition models
• High-dimensional inference for personalized treatment decision
• Investigation of age-treatment interaction in the SPACE trial using different statistical approaches
• Detecting an interaction between treatment and a continuous covariate: a comparison of two approaches
• Two‐stage penalized regression screening to detect biomarker–treatment interactions in randomized clinical trials

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