The linear stability of symmetric spike patterns for a bulk-membrane coupled Gierer-Meinhardt model
From MaRDI portal
Publication:5383207
Abstract: We analyze a coupled bulk-membrane PDE model in which a scalar linear 2-D bulk diffusion process is coupled through a linear Robin boundary condition to a two-component 1-D reaction-diffusion (RD) system with Gierer-Meinhardt (nonlinear) reaction kinetics defined on the domain boundary. For this coupled model, in the singularly perturbed limit of a long-range inhibition and short-range activation for the membrane-bound species, asymptotic methods are used to analyze the existence of localized steady-state multi-spike membrane-bound patterns, and to derive a nonlocal eigenvalue problem (NLEP) characterizing time-scale instabilities of these patterns. A central, and novel, feature of this NLEP is that it involves a membrane Green's function that is coupled nonlocally to a bulk Green's function. When the domain is a disk, or in the well-mixed shadow-system limit corresponding to an infinite bulk diffusivity, this Green's function problem is analytically tractable, and as a result we will use a hybrid analytical-numerical approach to determine unstable spectra of this NLEP. This analysis characterizes how the 2-D bulk diffusion process and the bulk-membrane coupling modifies the well-known linear stability properties of steady-state spike patterns for the 1-D Gierer-Meinhardt model in the absence of coupling. In particular, phase diagrams in parameter space for our coupled model characterizing either oscillatory instabilities due to Hopf bifurcations, or competition instabilities due to zero-eigenvalue crossings are constructed. Finally, linear stability predictions from the NLEP analysis are confirmed with full numerical finite-element simulations of the coupled PDE system.
Recommendations
- Spikes for the two-dimensional Gierer-Meinhardt system: the weak coupling case
- Multi-spike patterns in the Gierer-Meinhardt system with a nonzero activator boundary flux
- Synchronized oscillatory dynamics for a 1-D model of membrane kinetics coupled by linear bulk diffusion
- Spikes for the Gierer-Meinhardt system in two dimensions: the strong coupling case
- Stability analysis and simulations of coupled bulk-surface reaction-diffusion systems
Cites work
- scientific article; zbMATH DE number 1775466 (Why is no real title available?)
- A coupled bulk-surface model for cell polarisation
- A theory of biological pattern formation
- An explicitly solvable nonlocal eigenvalue problem and the stability of a spike for a sub-diffusive reaction-diffusion system
- Coupled bulk-surface free boundary problems arising from a mathematical model of receptor-ligand dynamics
- Erratum to: Turing instabilities in a mathematical model for signaling networks
- Hopf bifurcation of spike solutions for the shadow GiererMeinhardt model
- Hopf bifurcations and oscillatory instabilities of spike solutions for the one-dimensional Gierer-Meinhardt model
- Implicit-Explicit Methods for Time-Dependent Partial Differential Equations
- Implicit-explicit methods for reaction-diffusion problems in pattern formation
- Large stable pulse solutions in reaction-diffusion equations
- Mathematical aspects of pattern formation in biological systems
- On single interior spike solutions of the Gierer–Meinhardt system: uniqueness and spectrum estimates
- Simple computation of reaction-diffusion processes on point clouds
- Stability analysis and simulations of coupled bulk-surface reaction-diffusion systems
- Stability of spatially periodic pulse patterns in a class of singularly perturbed reaction-diffusion equations
- Symmetry breaking in a bulk-surface reaction-diffusion model for signalling networks
- The chemical basis of morphogenesis
- The stability of spike solutions to the one-dimensional Gierer-Meinhardt model
- Turing instabilities in a mathematical model for signaling networks
Cited in
(19)- Bulk-surface coupling: derivation of two models
- Stable asymmetric spike equilibria for the Gierer–Meinhardt model with a precursor field
- Stability of Turing bifurcation in a weighted networked reaction-diffusion system
- Spatiotemporal complexity in a Leslie-Gower type predator-prey model near Turing-Hopf point
- A stochastic-statistical residential burglary model with independent Poisson clocks
- Turing-Hopf bifurcation in diffusive Gierer-Meinhardt model
- Stability of Spike Solutions to the Fractional Gierer-Meinhardt System in a One-Dimensional Domain
- Multi-spike solutions to the one-dimensional subcritical fractional Schnakenberg system
- Analysis and asymptotic reduction of a bulk-surface reaction-diffusion model of Gierer-Meinhardt type
- Interactions Between Pelagic and Benthic Producers: Asymmetric Competition for Light and Nutrients
- Phytoplankton competition for nutrients and light in a stratified lake: a mathematical model connecting epilimnion and hypolimnion
- Existence and stability of symmetric and asymmetric patterns for the half-Laplacian Gierer-Meinhardt system in one-dimensional domain
- Stability analysis and simulations of coupled bulk-surface reaction-diffusion systems
- Turing patterning in stratified domains
- Dynamics of a depletion-type Gierer-Meinhardt model with Langmuir-Hinshelwood reaction scheme
- Existence and stability of a boundary layer with an interior spike in the singularly perturbed shadow Gierer-Meinhardt system
- Boundary layer solutions in the Gierer-Meinhardt system with inhomogeneous boundary conditions
- A martingale formulation for stochastic compartmental susceptible-infected-recovered (SIR) models to analyze finite size effects in COVID-19 case studies
- Multi-spike patterns in the Gierer-Meinhardt system with a nonzero activator boundary flux
This page was built for publication: The linear stability of symmetric spike patterns for a bulk-membrane coupled Gierer-Meinhardt model
Report a bug (only for logged in users!)Click here to report a bug for this page (MaRDI item Q5383207)
