A method to calculate binding equilibrium concentrations in the allosteric ternary complex model that supports ligand depletion

DOI10.1016/J.MBS.2011.05.003MaRDI QIDQ554482zbMATH OpenOpenAlexWikidataFDO

Authors Gilles Ph. Gnacadja

Publication date 4 August 2011

Published in Mathematical Biosciences (Search for Journal in Brave)

Full work available at URL https://doi.org/10.1016/j.mbs.2011.05.003

Mathematics Subject Classification ID

Probabilistic models, generic numerical methods in probability and statistics (65C20) Computational methods for problems pertaining to biology (92-08) Kinetics in biochemical problems (pharmacokinetics, enzyme kinetics, etc.) (92C45)

Recommendations

• Minimal models of multi-site ligand-binding kinetics
• Generalized concentration addition for ligands that bind to homodimers
• Ligand binding dynamics for pre-dimerised G protein-coupled receptor homodimers: linear models and analytical solutions
• A general model of multivalent binding with ligands of heterotypic subunits and multiple surface receptors
• Allostery in oligomeric receptor models
• Insights into the dynamics of ligand-induced dimerisation via mathematical modelling and analysis
• An algorithmic method for determining the kinetic system of receptor-channel complexes
• Variational implicit-solvent predictions of the dry–wet transition pathways for ligand–receptor binding and unbinding kinetics

Cites work

• scientific article; zbMATH DE number 45971 (Why is no real title available?)
• Fixed points of order-reversing maps in ℝn>0 and chemical equilibrium
• Univalent positive polynomial maps and the equilibrium state of chemical networks of reversible binding reactions

Cited in

(6)

• scientific article; zbMATH DE number 5885205 (Why is no real title available?)
• A Jacobian criterion for the simultaneous injectivity on positive variables of linearly parameterized polynomial maps
• Analysis of biochemical equilibria relevant to the immune response: finding the dissociation constants
• On the interaction of two different types of ligands binding to the same molecule. I: Basics and the transfer of the decoupled sites representation to systems with n and one binding sites
• Generalized concentration addition for ligands that bind to homodimers
• An invitation to pharmacostatics

This page was built for publication: A method to calculate binding equilibrium concentrations in the allosteric ternary complex model that supports ligand depletion

Report a bug (only for logged in users!)Click here to report a bug for this page (MaRDI item Q554482)