Optimal designs for dose finding studies with an active control

DOI10.1111/RSSB.12030MaRDI QIDQ5743271zbMATH OpenOpenAlexFDO

Authors Christine Kiss, Norbert Benda, Frank Bretz, Holger Dette

Publication date 9 May 2019

Published in Journal of the Royal Statistical Society Series B: Statistical Methodology (Search for Journal in Brave)

Full work available at URL http://hdl.handle.net/2003/29120

zbMATH Keywords

active controlBayesian optimal designsdose estimationdose responseminimax design

Mathematics Subject Classification ID

Minimax procedures in statistical decision theory (62C20) Bayesian inference (62F15) Optimal statistical designs (62K05) Applications of statistics to biology and medical sciences; meta analysis (62P10)

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Cited in

(9)

• Optimal approximate designs for comparison with control in dose-escalation studies
• Optimal designs for dose-finding studies
• Designing dose-finding studies with an active control for exponential families
• Optimal designs for active controlled dose-finding trials with efficacy-toxicity outcomes
• Non-parametric optimal design in dose finding studies
• Optimal designs for quasi-likelihood estimation in active controlled dose-finding trials
• The locally active-controlled optimal design: applications in oncology clinical studies
• Spline-based procedures for dose-finding studies with active control
• Design efficiency in dose finding studies

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