Spline-based procedures for dose-finding studies with active control

DOI10.1002/SIM.6320MaRDI QIDQ6918995zbMATH OpenFDO

Authors Hans-Joachim Helms, Norbert Benda, Jörg Zinserling, Thomas Kneib, Tim Friede

Publication date 9 October 2025

Published in Statistics in Medicine (Search for Journal in Brave)

Copyright license Creative Commons Attribution-NonCommercial 4.0 International

Full work available at URL https://europepmc.org/articles/pmc4288315

zbMATH Keywords

active controldesign considerationsdose-finding studyspline interpolation

Mathematics Subject Classification ID

Applications of statistics to biology and medical sciences; meta analysis (62P10)

Cites work

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• Multiple Test Procedures for Identifying the Minimum Effective and Maximum Safe Doses of a Drug
• On error bounds for spline interpolation
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• Optimal designs for dose-finding studies
• Optimal error bounds for cubic spline interpolation
• Response-adaptive dose-finding under model uncertainty

Cited in

(1)

• Optimal designs for quasi-likelihood estimation in active controlled dose-finding trials

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