A mathematical study for a Rotenberg model

Asymptotic behavior of solutions to PDEs (35B40) Qualitative properties of solutions to partial differential equations (35B99) PDEs in connection with biology, chemistry and other natural sciences (35Q92) Cell biology (92C37)

Review text

Assume that \(f=f(\mu,\nu,t)\) is the density of a cell population, where \(\mu\) is the degree of maturity, and \(\nu\) is the velocity of maturation. \textit{M. Rotenberg} [J. Theor. Biol. 103, No. 2, 181-199 (1983)] presented a model for \(f\): NEWLINE\[NEWLINE(1)\qquad \partial f/\partial t=-\nu\partial f/\partial \muNEWLINE\]NEWLINE with boundary condition NEWLINE\[NEWLINE(2)\qquad f(t,0,\nu)=\alpha f(t,1,\nu)+p\nu^{-1}\int_a^bk(\nu,\nu')\nu' f(t,1,\nu')d\nu',NEWLINE\]NEWLINE where \(k=k(\mu,\nu')\geq 0\) and NEWLINE\[NEWLINE(3)\qquad \int_a^bk(\nu,\nu')d\nu=1.NEWLINE\]NEWLINE Here, \(\nu\) and \(\nu'\) express daughter cell and mother cell, respectively, and \(0\leq p\) is the average number of viable daughters per mitotic in the degenerate case.NEWLINENEWLINENEWLINEThe author is concerned with the existence of a strongly continuous semigroup of the model (1)--(3) for all \(\alpha\geq 0\) and all \(p\geq 0\). Some properties, such as positivity, irreducibility, and asymptotic behavior in the uniform topology are also investigated. New techniques are introduced into the discussion.

Recommendations

Cites work

Cited in

(25)

This page was built for publication: A mathematical study for a Rotenberg model

Report a bug (only for logged in users!)Click here to report a bug for this page (MaRDI item Q5957736)