Bayesian modeling of multiple structural connectivity networks during the progression of Alzheimer's disease
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Abstract: Alzheimer's disease is the most common neurodegenerative disease. The aim of this study is to infer structural changes in brain connectivity resulting from disease progression using cortical thickness measurements from a cohort of participants who were either healthy control, or with mild cognitive impairment, or Alzheimer's disease patients. For this purpose, we develop a novel approach for inference of multiple networks with related edge values across groups. Specifically, we infer a Gaussian graphical model for each group within a joint framework, where we rely on Bayesian hierarchical priors to link the precision matrix entries across groups. Our proposal differs from existing approaches in that it flexibly learns which groups have the most similar edge values, and accounts for the strength of connection (rather than only edge presence or absence) when sharing information across groups. Our results identify key alterations in structural connectivity which may reflect disruptions to the healthy brain, such as decreased connectivity within the occipital lobe with increasing disease severity. We also illustrate the proposed method through simulations, where we demonstrate its performance in structure learning and precision matrix estimation with respect to alternative approaches.
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Cites work
- Bayesian inference of multiple Gaussian graphical models
- Decomposable graphical Gaussian model determination
- Efficient Gaussian graphical model determination under G-Wishart prior distributions
- Hyper Markov laws in the statistical analysis of decomposable graphical models
- Inference from iterative simulation using multiple sequences
- Joint estimation of multiple graphical models
- Joint estimation of precision matrices in heterogeneous populations
- Joint structural estimation of multiple graphical models
- Optimal predictive model selection.
- Scaling it up: stochastic search structure learning in graphical models
- Sparse inverse covariance estimation with the graphical lasso
- The Joint Graphical Lasso for Inverse Covariance Estimation Across Multiple Classes
Cited in
(19)- Dynamic and robust Bayesian graphical models
- Bayesian joint inference for multiple directed acyclic graphs
- Bayesian graphical models for modern biological applications
- Group guided fused Laplacian sparse group Lasso for modeling Alzheimer's disease progression
- Bayesian modeling of the structural connectome for studying Alzheimer's disease
- Dynamic modeling of multivariate dimensions and their temporal relationships using latent processes: application to Alzheimer's disease
- Bayesian Spatial Binary Regression for Label Fusion in Structural Neuroimaging
- Extracting brain disease‐related connectome subgraphs by adaptive dense subgraph discovery
- A Bayesian latent spatial model for mapping the cortical signature of progression to Alzheimer's disease
- A Bayesian Subset Specific Approach to Joint Selection of Multiple Graphical Models
- Predicting progression of Alzheimer's disease using forward-to-backward bi-directional network with integrative imputation
- Identifying Brain Hierarchical Structures Associated with Alzheimer's Disease Using a Regularized Regression Method with Tree Predictors
- Mapping the Genetic-Imaging-Clinical Pathway with Applications to Alzheimer’s Disease
- Topological dissimilarities of hierarchical resting networks in type 2 diabetes mellitus and obesity
- Bayesian Multi-Task Variable Selection with an Application to Differential DAG Analysis
- Analysis of heterogeneous networks with unknown dependence structure
- Inference of Multiple High-Dimensional Networks with the Graphical Horseshoe Prior
- Bayesian functional graphical models with change-point detection
- The multiple graphical horseshoe: an application to breast cancer data
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