Probabilistically certified region of attraction of a tumor growth model with combined chemo‐ and immunotherapy

DOI10.1002/RNC.6158MaRDI QIDQ6061072zbMATH OpenOpenAlexFDO

Authors Kaouther Moussa, Mirko Fiacchini, Mazen Alamir

Publication date 2 December 2023

Published in International Journal of Robust and Nonlinear Control (Search for Journal in Brave)

Full work available at URL https://arxiv.org/abs/2004.14077

zbMATH Keywords

cancer dynamical systemsdomain of attraction estimationparametric uncertaintiesprobabilistic certificationrandomized algorithms

Mathematics Subject Classification ID

Pathology, pathophysiology (92C32) Medical applications (general) (92C50)

Abstract: This paper deals with the estimation of regions of attraction (RoAs) under parametric uncertainties for a cancer growth model with combined therapies. We propose a framework of probabilistic certification, based on the randomized methods, in order to derive probabilistically certified RoAs of a cancer growth model. The model that we consider in this paper describes the interaction between tumor and immune system in presence of a combined chemo- and immunotherapy. Furthermore, we model the concentration of the chemotherapy agent in the body via a pharmacokinetic equation.

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