Assessing the Most Vulnerable Subgroup to Type II Diabetes Associated with Statin Usage: Evidence from Electronic Health Record Data
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Publication:6077533
Abstract: There have been increased concerns that the use of statins, one of the most commonly prescribed drugs for treating coronary artery disease, is potentially associated with the increased risk of new-onset type II diabetes (T2D). Nevertheless, to date, there is no robust evidence supporting as to whether and what kind of populations are indeed vulnerable for developing T2D after taking statins. In this case study, leveraging the biobank and electronic health record data in the Partner Health System, we introduce a new data analysis pipeline and a novel statistical methodology that address existing limitations by (i) designing a rigorous causal framework that systematically examines the causal effects of statin usage on T2D risk in observational data, (ii) uncovering which patient subgroup is most vulnerable for developing T2D after taking statins, and (iii) assessing the replicability and statistical significance of the most vulnerable subgroup via a bootstrap calibration procedure. Our proposed approach delivers asymptotically sharp confidence intervals and debiased estimate for the treatment effect of the most vulnerable subgroup in the presence of high-dimensional covariates. With our proposed approach, we find that females with high T2D genetic risk are at the highest risk of developing T2D due to statin usage.
Cites work
- L 1-Regularization Path Algorithm for Generalized Linear Models
- A modern maximum-likelihood theory for high-dimensional logistic regression
- Bootstrap confidence intervals and hypothesis tests for extrema of parameters
- Confidence intervals for low dimensional parameters in high dimensional linear models
- Confidence intervals for the means of the selected populations
- Debiased Inference on Treatment Effect in a High-Dimensional Model
- Debiasing the debiased Lasso with bootstrap
- Estimating Individual Treatment Effect in Observational Data Using Random Forest Methods
- Estimation following selection of the largest of two normal means
- Exploratory subgroup analysis in clinical trials by model selection
- High-dimensional simultaneous inference with the bootstrap
- scientific article; zbMATH DE number 1487684 (Why is no real title available?)
- Inference for subgroup analysis with a structured logistic-normal mixture model
- Inference of high-dimensional linear models with time-varying coefficients
- Inference on Selected Subgroups in Clinical Trials
- On overfitting and post-selection uncertainty assessments
- Statistics and Causal Inference
- Tweedie’s Formula and Selection Bias
Cited in
(7)- Exploratory subgroup identification in the heterogeneous Cox model: a relatively simple procedure
- Estimation of the interpretable heterogeneous treatment effect with causal subgroup discovery in survival outcomes
- Heterogeneous Functional Regression for Subgroup Analysis
- Inference with combined data from subgroup selection and validation phases in clinical trials
- A penalized regression-based biclustering approach in gene expression data
- Bayesian variable selection on structured logistic-normal mixture models for subgroup analysis
- Varying treatment effects in subgroups: a unified framework for longitudinal data analysis
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