Classifying the post-duplication fate of paralogous genes

DOI10.1007/978-3-031-36911-7_1MaRDI QIDQ6086491zbMATH OpenFDO

Authors Reza Kalhor, G. Beslon, Manuel Lafond, Celine Scornavacca

Publication date 12 December 2023

Published in Comparative Genomics (Search for Journal in Brave)

Full work available at URL https://doi.org/10.1007/978-3-031-36911-7_1

zbMATH Keywords

classificationduplication fatesgene duplicationparalogysimulation

Mathematics Subject Classification ID

Computational methods for problems pertaining to biology (92-08) Genetics and epigenetics (92D10)

Review text

The paper describes a computational framework for the characterisation of duplicated genes and a formal feature-based differentiation of fates which allows the identification of novel patterns. To illustrate the steps, the authors simulate the evaluation of populations using aevol. The post-duplications fates described in detail include pseudogenization, double-neofunctionalisation, conservation, subfunctionalisation and specialisation. All mathematical and computational aspects of the study are described in detail. For the entire collection see [Zbl 1525.92003].

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Cites work

• Comparative genomics on artificial life
• Evolutionary coupling between the deleteriousness of gene mutations and the amount of non-coding sequences
• Level-dependent QBD models for the evolution of a family of gene duplicates

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