Discrete-Time System of an Intracellular Delayed HIV Model with CTL Immune Response

DOI10.1007/978-3-031-17558-9_12zbMATH Open1521.92096arXiv2205.02199OpenAlexW4229037684MaRDI QIDQ6094985FDOQ6094985

Authors: Delfim F. M. Torres 

Publication date: 15 September 2023

Published in: Dynamic Control and Optimization (Search for Journal in Brave)

Abstract: In [Math. Comput. Sci. 12 (2018), no. 2, 111--127], a delayed model describing the dynamics of the Human Immunodeficiency Virus (HIV) with Cytotoxic T Lymphocytes (CTL) immune response is investigated by Allali, Harroudi and Torres. Here, we propose a discrete-time version of that model, which includes four nonlinear difference equations describing the evolution of uninfected, infected, free HIV viruses, and CTL immune response cells and includes intracellular delay. Using suitable Lyapunov functions, we prove the global stability of the disease free equilibrium point and of the two endemic equilibrium points. We finalize by making some simulations and showing, numerically, the consistence of the obtained theoretical results.

Full work available at URL: https://arxiv.org/abs/2205.02199

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zbMATH Keywords

compartmental modelsLyapunov functionsstability analysisMickens method

Mathematics Subject Classification ID

Epidemiology (92D30) Qualitative investigation and simulation of models involving functional-differential equations (34K60) Applications of difference equations (39A60)

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Cited In (1)

• A discrete model for HIV infection with distributed delay

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