Discrete-Time System of an Intracellular Delayed HIV Model with CTL Immune Response

DOI10.1007/978-3-031-17558-9_12MaRDI QIDQ6094985zbMATH OpenOpenAlexFDO

Authors Delfim F. M. Torres

Publication date 15 September 2023

Published in Dynamic Control and Optimization (Search for Journal in Brave)

Full work available at URL https://arxiv.org/abs/2205.02199

zbMATH Keywords

compartmental modelsLyapunov functionsstability analysisMickens method

Mathematics Subject Classification ID

Epidemiology (92D30) Qualitative investigation and simulation of models involving functional-differential equations (34K60) Applications of difference equations (39A60)

Abstract: In [Math. Comput. Sci. 12 (2018), no. 2, 111--127], a delayed model describing the dynamics of the Human Immunodeficiency Virus (HIV) with Cytotoxic T Lymphocytes (CTL) immune response is investigated by Allali, Harroudi and Torres. Here, we propose a discrete-time version of that model, which includes four nonlinear difference equations describing the evolution of uninfected, infected, free HIV viruses, and CTL immune response cells and includes intracellular delay. Using suitable Lyapunov functions, we prove the global stability of the disease free equilibrium point and of the two endemic equilibrium points. We finalize by making some simulations and showing, numerically, the consistence of the obtained theoretical results.

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Cited in

(1)

• A discrete model for HIV infection with distributed delay

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